原发性肝癌合并门静脉癌栓血液动力学变化的多层螺旋CT灌注成像研究  

Study on Hemodynamic Changes on Multi-slice CT Perfusion Imaging in Primary Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

作　　者：戚跃勇[1] 邹利光[1] 王细文[1] 孙清荣[1] 郝萍[1] 刘卫金[1] 戴书华[1] 王智平[1] 

机构地区：[1]第三军医大学新桥医院,重庆400037

出　　处：《肿瘤学杂志》2007年第3期204-207,共4页Journal of Chinese Oncology

基　　金：GE公司联合研发基金(2004E039)

摘　　要：[目的]通过多层螺旋CT(MSCT)灌注成像探讨原发性肝癌合并门静脉癌栓(PVTT)的血液动力学变化。[方法]对84例受试对象行MSCT灌注扫描。计算肝血流量(HBF)、肝血容量(HBV)、平均通过时间(MTT)、毛细血管表面通透性(PS)和肝动脉灌注指数(HAF)。[结果]实验A组肿瘤组织的HBF、HAF[(435.31±89.21)ml/(100g·min),0.87±0.26]明显高于阳性对照B组[(365.71±67.38)ml/(100g·min),0.72±0.23],实验A组PVTT组织的HBV、HAF[(44.72±11.62)ml/100g,0.93±0.14]也明显高于阳性对照B组[(30.38±28.61)ml/100g,0.72±0.23](P<0.05),而实验A组肿瘤组织的MTT值却短于阳性对照B组[(5.73±4.28)s,(8.22±3.51)s](P<0.05)。实验A组异常灌注组织的HBF、HBV和HAF值均明显高于阴性对照C组。[结论]MSCT灌注参数可反映原发性肝癌合并门静脉癌栓血液动力学变化。[Purpose]To study hemodynamic changes on multi-slice CT （MSCT） perfusion imaging in primary hepatocellular carcinoma（HCC） with portal vein tumor thrombus （PVTT）. [Methods] MSCT perfusion imaging was performed with a spiral CT scanner in 84 patients. Total hepatic blood flow（HBF）, hepatic blood volume（HBV）, mean transit time（MTT）, permeability surface （PS） and hepatic arterial fraction （HAF） were measured. [Results] Compared with the positive control group B, the HBF and HAF of the tumor tissues in test group A increased significantly [（435.31±89.21）ml/（100g·min） vs.（365.71±67.38）ml/（100g·min）, （0.87±0.26） vs.（0.72±0.23）], and also the HBV and HAF of the PVTT in test group A [（44.72±11.62）ml/100g vs. （30.38±28.61）ml/100g, （0.93±0.14） vs.（0.72±0.23）] （P〈0.05）. However, the MTT of the tumor tissues in test group A was shorter significantly than that in positive control group B [（5.73±4.28）s vs.（8.22±3.51）s, P〈0.05]. Compared with the negative control group C, the HBF, HBV and HAF of the hyperperfusion abnormality tissues in test group A increased significantly. [Conclusion] MSCT perfusion parameters may reflect the hemodynamic change of HCC with PVTT.

关 键 词：体层摄影术 X线计算机 癌 肝细胞 门静脉 瘤栓 血流灌注 

分 类 号：R735.7[医药卫生—肿瘤]