肝靶向甘草次酸修饰的壳聚糖纳米粒子的合成和表征  

Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier

作　　者：查瑞涛[1] 贺晓婷[1] 杜田[1] 袁直[1] 

机构地区：[1]南开大学高分子化学研究所功能高分子材料教育部重点实验室

出　　处：《高等学校化学学报》2007年第6期1098-1100,共3页Chemical Journal of Chinese Universities

基　　金：教育部天津大学-南开大学科技合作基金;天津市自然科学基金(批准号:07JCZDJC00700)资助

摘　　要：Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochemical properties of these nanoparticles were investigated by using TEM and DLS.The experiment in vitro BSA entrapped was studied.GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.Chitosan derivative with glycyrrhetinic acid （GA）, which was accumulated specifically in liver, was synthesized. By ion-crosslinking of TPP in GA-CTS solution, GA-CTS-TPP complex nanoparticles were obtained. The physicochemical properties of these nanoparticles were investigated by using TEM and DLS. The experiment in vitro BSA entrapped was studied. GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.

关 键 词：甘草次酸 壳聚糖 肝靶向 

分 类 号：O625[理学—有机化学]