适形放射治疗联合热疗治疗晚期胰腺癌的疗效及临床受益反应观察  

Conformal radiotherapy combined with hyperthermia for advanced,unresectable pancreatic cancer

作　　者：于清蕊[1] 祝沈冬[1] 段宏燕[1] 鞠艳[1] 李沈峪[1] 

机构地区：[1]辽宁省肿瘤医院放疗科,辽宁沈阳110042

出　　处：《中华肿瘤防治杂志》2007年第11期858-859,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了评价适形放疗联合热疗治疗晚期胰腺癌的疗效及临床受益反应,对34例胰腺癌患者给予适形放疗,2Gy/次,5次/周,总剂量50-70 Gy;热疗2次/周,每次60-90 min,共计6次。结果82.4%患者胸背部疼痛明显缓解,临床受益反应有效率91.2%;放疗后2个月复查CT,肿瘤缩小〉25%者76.5%;1、2年生存率分别为38.2%和20.6%。初步研究结果提示,适形放射治疗联合热疗治疗晚期胰腺癌,疗效较好,并发症少,可显著提高患者生活质量,是不能手术患者较好的治疗方式。The objective of this study was to evaluate the therapeutic effect of conformal radiotherapy combined with concurrent hyperthermia on advanced, unresectable pancreatic cancer. Thirty-four patients with advanced pancreatic carcinoma received conformal radiotherapy with 2 Gy/fraction, 5 fraction/week,a total dose 50-70 Gy, and at the same time, hyperthermia was pertormed, twice a week for 6 fraction, 60-90 minutes/fraction. Results： 82.4% of the patients who suffered from pain got relief, and the clinical benefit reponse was 91.2%. The over all response rate （CR＋PR） were 76.5%, and 1-year and 2year survival rates were 38.2% and 20.6%. Conclusion： The conformal radiotherapy combined with concurrent hyperthermia is an effective approach to improve life quality and prolong survival time for unresectable pancreatic carcinoma.

关 键 词：胰腺肿瘤/放射疗法 放射疗法 适形 临床受益反应 热疗 

分 类 号：R735.9[医药卫生—肿瘤]