前列腺癌患者血清中铜、锌与铜/锌比值的变化及意义  

Significance of trace elements copper and zinc change in the serum of patients with prostate cancer

作　　者：汲坤[1] 张灵[1] 邵月婷[1] 田勇[1] 梁作文[1] 刘亚男[1] 李晓萌[1] 李扬[1] 赵雪俭[1] 

机构地区：[1]吉林大学基础医学院病理生理教研室暨吉林大学前列腺疾病防治研究中心,长春130021

出　　处：《中国男科学杂志》2007年第5期9-10,14,共3页Chinese Journal of Andrology

基　　金：科技部国际科技合作重点项目(2004DFB02000);吉林省科技发展计划项目(20030710)

摘　　要：目的探讨血清铜、锌含量与前列腺癌之间的关系,并将其与血清前列腺特异性抗原(PSA)比较,探讨其在前列腺癌诊断中价值比较。方法采用原子吸收分光光度法测定76例前列腺癌患者、125例前列腺增生患者和191例健康男性的血清铜、锌含量。结果前列腺癌组血清锌明显低于健康对照组,血清铜和铜/锌比值明显高于健康对照组(P<0.05)。前列腺癌组血清铜及铜/锌比值与前列腺增生组比较未见显著性差异;前列腺癌组血清锌低于前列腺增生组(P<0.05)。前列腺增生组血清锌与健康对照组比较未见显著性差异;前列腺增生组血清铜和铜/锌比值高于健康对照组(P<0.05)。PSA在4.0-10.0ng/ml灰色区域的前列腺癌组,血清锌ROC-AUC(receiver operator characteristic curve-area under curve)为66%,高于PSA的ROC-AUC。结论血清铜、铜/锌比值升高及血清锌降低可能是前列腺癌发生的危险因素,血清锌在PSA(4.0～10.0)ng/ml灰色区域的前列腺癌诊断效率高于PSA,其可能为前列腺癌的诊断提供有价值的指标。Objective To explore the association between the concentrations of serum trace elements and prostate cancer. Methods The concentrations of serum zinc and copper were determined by atomic absorption spectrophotometer in 76 patients with prostate cancer, 191 healthy subjects and 125 patients with hyperplasia of prostate gland. Results The concentrations of serum copper and copper/zinc in patients with prostate cancer were higher than in healthy subjects, the concentrations of serum zinc in patients with prostate cancer were significantly lower than in healthy subjects （P〈 0.05）.Otherwise the concentrations of serum zinc and copper had no difference between in patients with prostate cancer and hyperplasia of prostate gland. Conculsion The higher serum copper, copper/zinc and the lower serum zinc might serve as risk factors to induce the prostate cancer, these changes may be used as an auxiliary marker in the field of diagnosis of prostate cancer.

关 键 词：前列腺肿瘤 铜 锌 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]