间隙连接蛋白家族的研究进展  

Progress in protein families of gap junction

作　　者：辛莉[1] 郭国庆[1] 沈伟哉[1] 

机构地区：[1]暨南大学医学院解剖学教研室,广东广州510630

出　　处：《中国病理生理杂志》2007年第6期1240-1243,共4页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金团队项目(No.039213);广州市科技计划项目(No.2004J1-C0214)

摘　　要：Gap junctions are intercellular channels, which connect adjacent cells and allow direct molecular exchange of low molecular weight between them. Three protein families including connexins, innexins and ponnexins are involved in gap junctions. Connexins are only found in chordate and innexins compose the gap junctions of invertebrates, while pannexins are ubiquitous and present in both vertebrates and invertebrates. Gap junctions in metazoan play important roles in electrical coupling, regulating proliferation, differentiation, and embryonic development. Evidently, the defects of gap junctions resulting form proteins contribute to many diseases of vertebrates and invertebrates, such as tumor, heart diseases, nervous system disorders and other diseases in human.Gap junctions are intercellular channels, which connect adjacent cells and allow direct molecular exchange of low molecular weight between them. Three protein families including connexins, innexins and Ponnexins are involved in gap junctions. Connexins are only found in chordate and innexins compose the gap junctions of invertebrates, while pannexins are ubiquitous and present in both vertebrates and invertebrates. Gap junctions in metazoan play important roles in electrical coupling, regulating proliferation, differentiation, and embryonic development. Evidently, the defects of gap junctions resulting form proteins contribute to many diseases of vertebrates and invertebrates, such as tumor, heart diseases, nervous system disorders and other diseases in human.

关 键 词：缝隙接合部 连接蛋白类 Innexins Ponnexins 

分 类 号：R363[医药卫生—病理学]