三吡萘啶对伯氏疟原虫ANKA株超微结构的影响  

An Ultrastructurat Study of the Effects of Tripynadine on Plasmodium Berghei ANKA Strain

作　　者：陈林[1] 戴祖瑞[1] 张淑英[1] 陆月良[2] 

机构地区：[1]第二军医大学抗疟药研究室 [2]第二军医大学中心实验室 [3]广州中医药大学热带医学研究所

出　　处：《广州中医药大学学报》1997年第1期34-36,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金

摘　　要：受染伯氏疟原虫ＡＮＫＡ株小鼠ｉｇ三吡萘啶游离碱１１ｍｇ／ｋｇ．１ｈ后可见少数滋养体复合物层次增多且断裂、皱缩，并出现间隙，食物泡融合增大。２ｈ后进一步加剧，且疟原虫髓样物也增多，线粒体肿胀。４ｈ后出现变化的原虫更明显增多。８ｈ后绝大多数滋养体结构多已瓦解，仅留下残体及大小不等的空泡。总之。Tripynadine, 2_pyrrolidino_7_chloro_10_3',5_bis (pyrrolidino_1_methyl)_4'_hydroxyphenyl amino_benzo(b)1,5_naphthyiridine, is superiror to pyronaridine in residual antimalarial acivity for mice and monkeys malaria. The effect of tripynadine free base (11mg/kg, the dose of ED 50 )on the fine structurel of the erythrocytic stages of P.berghei ANKA strain indicated than tripynadine exerted a potent and rapid lethal action on the erythrocytic forms by interfering the physiological function of pellicular complexes and food vacuoles. A proportion of trophozoites showed progressive morphological changes such as swelling, breaking and shrinking of multilamellate whorls of pellicular complexes, And interspaces appeared and fusion of food vacuoles increased 1h after medication, 2h after medication, the above changes became more severe and myel_like materials in the parasites increased. Mitochondia became swollen. At 4h after exposure to tripynadine, the pathologically changing parasites increased significantly. 8h after medication, the small disrupted membranous residues and dead parasites were detected. In short, the ultrastructural changes of trophozoites elictedly tripynadine were approximately similar to those by pyronaridine.

关 键 词：三吡萘啶 药理学 伯氏疟原虫 超微结构 药物作用 

分 类 号：R978.61[医药卫生—药品]