烟碱型乙酰胆碱受体与临床疾病  

Nicotinic acetylcholine receptor and clinical diseases

作　　者：周国勇[1] 胡森[1] 

机构地区：[1]解放军总医院第一附属医院全军烧伤研究所休克与多器官障碍实验室,北京100037

出　　处：《基础医学与临床》2007年第5期584-587,共4页Basic and Clinical Medicine

基　　金：军队医药卫生十一五专项课题(06Z055)

摘　　要：烟碱型乙酰胆碱受体(nAChR)是配体门控的离子通道受体家族成员,广泛分布于中枢神经、神经肌肉接头以及其他细胞表面。构成亚基不同和分布部位的差异表现为受体功能的多样性。早期研究发现,nAChR主要与神经电信号传导有关;近期研究认为它是胆碱能抗炎通路的关键受体。阐明这些功能的生理机制对重症肌无力、癫痫以及多器官衰竭等相关疾病有重要的临床意义。Nicotinic acetylcholine receptors （nAChRs） construct a family of ligand-gated ion channels, nAChRs distribute extensively in central nerve system, neuromuscular junctions and surface of other cells. The differences on subunits and tissue location determinate the diversity of receptor functions. Early research has found that nerve signal transmission is its main function and recent research found it also the key receptor of cholinergic anti-inflammatory pathway. To illuminate the physiological mechanism of these functions has great clinical significance for the treatment of correlated diseases such as myasthenia gravis, epilepsy and multiple organ failure.

关 键 词：乙酰胆碱受体 烟碱 离子通道 炎症 

分 类 号：R363[医药卫生—病理学]