唐山震后有机氯农药残留与乳腺癌的相关性研究  

STUDY ON THE RELATIONSHIP BETWEEN ORGANOCHLORINE PESTICIDES RESIDUES AFTER TANGSHAN EARTHQUAKE AND BREAST CANCER

作　　者：荣素英[1] 李君[1] 牛风玲[2] 张国志[3] 姚三巧[1] 王茂清[1] 

机构地区：[1]河北华北煤炭医学院预防医学系 [2]唐山市肿瘤医院 [3]华北煤炭医学院附属医院

出　　处：《现代预防医学》2007年第11期2079-2081,2084,共4页Modern Preventive Medicine

摘　　要：[目的]探讨唐山震后有机氯农药残留与乳腺癌的关系。[方法]应用病例对照研究,采用气相色谱法测定30对乳腺癌病例和对照的脂肪组织样品中有机氯农药滴滴涕(DDT)和六六六(HCH)的残留量。[结果]两组检出率比较差异无统计学意义;唐山震后农药不同暴露地区及唐山不同居住年限体内总DDT残留水平差异均有统计学意义,但总HCH水平差异无统计学意义;病例组与对照组两组总DDT、总HCH水平差异无统计学意义;总HCH高残留组(﹥0.085mg/kg)患乳腺癌的危险性是低残留组(≤0.085mg/kg)的4.49倍,但未显示总DDT高残留与乳腺癌发病有关联。[结论]有机氯农药六六六(HCH)高残留增加乳腺癌的发病危险。[Objective] To explore the relationship between organochlofine pesticides residues after Tangshan earthquake and breast cancer. [Methods] A case-control study was made in the study and the residues of DDT and HCH in adipose tissues from 30 pairs of cases and controls were measured by gas chromatography （GC） . [ Results] There was no statistical significance in the detection rates between the two groups. There were statistical significances in the levels of sum DDT in different exposure areas and different years of residence in Tangshan, but there was no statistical significance in the levels of sum HCH. The levels of sum DDT and HCH were not statistically different between cases and controls. Compared with low residues （sum HCH≤0.085 mg/kg） group, a significantly elevated risk of breast cancer was observed for high residues （sum HCH 〉 0.085 mg/kg）, and OR value was 4.49, but there was no association between the sum DDT residues and breast cancer. [Conclusion] High HCH residues is significantly associated with the increase of risk of breast cancer.

关 键 词：乳腺癌 滴滴涕(DDT) 六六六(HCH) 内分泌干扰物 

分 类 号：R737.9[医药卫生—肿瘤]