肉桂醛、柠檬醛对烟曲霉色素及关键基因alb1 mRNA表达的影响  

The Influence of Cinnamldehyde and Citral on the Pigmentand the mRNA Expression of alb1 Gene of Aspergillus fumigatus

作　　者：龙凯[1] 谢小梅[2] 方建如[2] 旷雅舒[3] 

机构地区：[1]江西中医学院药学系,南昌330004 [2]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [3]南昌大学生命科学院,南昌330047

出　　处：《微生物学通报》2007年第3期541-544,共4页Microbiology China

基　　金：国家自然科学基金资助项目(No.30160099)

摘　　要：研究了肉桂醛、柠檬醛对烟曲霉色素及其关键基因alb1 mRNA表达的影响。结果表明随着肉桂醛、柠檬醛浓度的增加,菌苔逐渐变稀、薄且烟绿色色素逐渐变淡,甚至白化;肉桂醛、柠檬醛对alb1基因mRNA表达有明显抑制作用,随着药物浓度的降低这种抑制作用亦相应呈现不同程度的减弱,肉桂醛、柠檬醛可能通过抑制alb1 mRNA的表达导致烟曲霉缺失烟绿色色素。The influence of the active ingredients of citral and cinn on the pigment and the mRNA expressions of albl gene of Aspergillus fumigatus were studied. Results indicated that in Czapak＇ s solid culture medium,the higher the concentration of ingredient was,the thinner the lawn would be, and the pigment became lighter and lighter gradually, even white; citral and cinn could obviously repress the expressions of alb 1 gene and this effect was weakened by lower concentrations, The two can avaliably suppress the mRNA expression of alb 1 gene which is essential for the biosynthesis of Aspergillus fumigatus ＇ s pigment.

关 键 词：肉桂醛 柠檬醛 烟曲霉色素 RT-PCR 

分 类 号：R285.5[医药卫生—中药学]