VEGF-C在宫颈病变中的表达及其与高危型HPV感染的相关性  

Relations between the expression of VEGF-C and high risk HPV in human cervical cancer and pre-malignant lesion

作　　者：李艳丽[1] 郑红兵[1] 李允光[1] 汪爱华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《现代肿瘤医学》2007年第6期834-837,共4页Journal of Modern Oncology

摘　　要：目的:研究VEGF-C在宫颈癌及癌前病变(CIN)组织中的表达及其与高危型HPV感染的相关性,探讨其在宫颈癌发生发展中的意义。方法:采用免疫组织化学SABC法检测100例宫颈石蜡标本中VEGF-C的表达,并于术前采用HC-Ⅱ法检测患者高危型HPV感染情况。结果:VEGF-C和高危型HPV在宫颈癌及CIN中的表达水平均高于正常宫颈组织,差异有统计学意义(P<0.05);在宫颈癌及CIN中VEGF-C表达水平和高危型HPV感染率成正相关(P<0.05)。结论:高危型HPV可能通过诱导宫颈上皮高表达VEGF-C而促使宫颈癌发生发展。Objective： To study the expression of VEGF- C, high risk HPV （HR - HPV） in cervical cancer and pre - malignant lesion , and discuss the role of them in occurrence and development of cervical cancer. Methods ： In 100 cases including 10 cases of normal cervical tissues,50 cases of CIN and 40 cases of cervical cancer tissues,the expression of VEGF - C was detecteat by immunohistochemistry SABC assay , and HR - HPV infection levels were detected by HC - Ⅱ before operation. Results： VEGF - C and HR - HPV were both overexpressed in cervical cancer and CIN ,compared with normal cervical tissues （P 〈 0.05 ）. In cervical cancer samples and CIN samples, the expression level of VEGF - C was positive associated with HR - HPV infection （ P 〈 0.05 ）. Conclusion： VEGF - C may play vital roles in the tumorigenesis and development of the HR - HPV - related cervical neoplasms.

关 键 词：VEGF—C HPV CIN 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]