可变误差多面体分光光度法同时测定撒痛风注射液中3组分的含量  

Simultaneous Spectrophotometric Determination of Three Components in Satongfeng Injection by Flexible Tolerance Simplex Method

作　　者：魏得良[1] 郭皖北[1] 黄志红[1] 周明达[2] 王曼娟[2] 刘建华[2] 

机构地区：[1]湘南学院化学与生命科学系,郴州市423000 [2]中南大学化学化工学院,长沙市410078

出　　处：《中国药房》2007年第16期1250-1252,共3页China Pharmacy

基　　金：湖南教育厅课题资助项目(05C630)

摘　　要：目的:建立同时测定撒痛风注射液中3组分含量的方法。方法:在258～290nm波长范围内,间隔1nm,取33个波长进行测定,并采用可变误差多面体法对多波长分光光度数据进行处理。结果:水杨酸钠、安替比林、咖啡因的线性范围分别为0～42、0～12、0～6μg.mL-1;平均回收率分别为(99.93±0.22)%、(99.85±0.24)%、(100.19±0.40)%,与标准方法基本吻合。结论:该方法具有操作简便、快速、重现性好,易于实现自动分析的优点,可用于该制剂的质量控制。OBJECTIVE： To establish a method for simultaneous determination of the contents of three components in synthesis and actual satongfeng injection. METHODS： A flexible tolerance simplex method was used for multi - wavelength spectrophotometry with interval of lnm in 258--290nm wavelenth, 33 wavelenths were selected. RESULTS： The linear range and average recoveries rate of sodium salicylate, phenazone and caffeine were 0--42, 0--12, 0--6μg·mL^-1 and （99.93 ± 0.22） %, （99.85 ± 0.24） % and （100.19 ± 0.40） % respectively. All were agreed with those by standard method. CONCLUSIONS： This method is easy in operation, fast and reproducible, applicable to automatic analysis, and therefore can be used for the quality control of the preparation.

关 键 词：可变误差多面体法 紫外分光光度法 撒痛风注射液 水杨酸钠 安替比林 咖啡因 含量测定 

分 类 号：R927.2[医药卫生—药学] R971.1