2%过氧乙酸吸入毒性实验  

Toxicity Caused by Inspiration of 2% Peracetic Acid Aerosol in Rats

作　　者：张大维[1] 邴国强[2] 徐彩云[1] 李萍[2] 杨东华[3] 于艳波[3] 刘占军[4] 郭超 

机构地区：[1]吉林大学基础医学院动物实验中心,吉林长春130021 [2]吉林大学体育学院实验中心,吉林长春130012 [3]吉林大学第二临床医学院实验动物观察室 [4]长春生物制品研究所实验动物室 [5]长春精优药业股份有限公司

出　　处：《中国比较医学杂志》2007年第6期351-352,356,共3页Chinese Journal of Comparative Medicine

基　　金：吉林省科技发展计划项目(项目编号吉科合字第20000200号)

摘　　要：目的观察2%含量的过氧乙酸溶液气溶胶喷雾,对实验动物和工作人员产生的毒性作用。方法利用隔离器,观察2%含量的过氧乙酸溶液喷雾消毒,达到1 g/m3浓度,维持4 h,通过行为学测试和病理学解剖结果,判定大鼠吸入后,所产生的毒性作用。结果2%过氧乙酸溶液喷雾消毒后,在4 h～7 d间大鼠出现行为活动异常。结论2%过氧乙酸溶液喷雾消毒,浓度为1 g/m3时,对动物有毒性作用。Objective To assess the toxic effect of 2% peracetic acid aerosol disinfection on laboratory animals and the staff. Method Isolator was disinfected with 2% peracetic acid aerosol at concentration of 1 g/m^3 density for 4 hours. Rats were kept in the isolator and their behavior and pathological changes were observed to assess whether inspiration of the aerosol lead to toxicity in the rats. Results After 2 % peracetic acid aerosol inspiration for 4 hours, the rats depicted abnormal behavior activity during 4 hours to 7 days. Conclusions 2% peracetic acid aerosolat using a density of 1 g/m^3 is toxic to laboratory animals.

关 键 词：过乙酸 消毒 毒性作用 

分 类 号：R-33[医药卫生]