脑膜癌病59例临床分析  

Clinical analysis of 59 cases of meningeal careinomatosis

作　　者：孙琦[1] 王立[1] 张贞浏[1] 

机构地区：[1]南京医科大学附属脑科医院神经内科,210029

出　　处：《临床神经病学杂志》2007年第3期200-202,共3页Journal of Clinical Neurology

摘　　要：目的探讨脑膜癌病(MC)的临床和脑脊液(CSF)细胞学特征。方法回顾性分析59例确诊为MC患者的临床资料。结果本组中老年患者占91.5%(54例);呈亚急性或急性起病,病情进展较快;疾病早期多不发热(55例,93.2%);头痛(57例)、呕吐(45例)及视盘水肿(21例)等颅内压增高症状为突出表现;32例(54.2%)出现脑神经受累,以视神经、展神经受累多见,其次为动眼神经、面神经及前庭蜗神经等;59例均有脑膜刺激征,其中31例(52.5%)较明显;59例CSF细胞学检查均找到癌细胞。结论MC的临床表现具有一定的特征,确诊依赖于CSF细胞学检查找到癌细胞。Objective To discuss clinical and cytological features of cerebrospinal fluid （CSF） in meningeal careinomatosis （ MC ）. Methods The data of clinic, imaging and CSF of 59 inpatients with MC were analyzed retrospectively. Results There were 91.5% （54 cases ） of middle and elder aged in the group. Most of patients were at acute or subacute onset . Condition developed fast. 55 cases （93. 2% ） didn＇t feel fever primarily. Intracranial hypertension of headache （57 cases ）, vomitted（45 cases ） and disc edema（21 cases ） ect. were predominant features. In 32 cases （54.2%） , cranial nerves were involved. Optic never and abducent never damage appeared the most frequently. Oculomotor never, facial nerve and vestibulocochlear nerve were in the next. All of 59 cases had meningeal irritation sign, among them 31 cases （52.5%） with obvious sign. Tumor cells in cytological examination of CSF were found in all of 59 cases. Conclusions The clinical manifestations of MC has some certain features. Diagnosis of MC still relay on finding tumor cells in cytological examination of CSF.

关 键 词：脑膜癌病 脑脊液 细胞学 

分 类 号：R739.45[医药卫生—肿瘤]