血清胃蛋白酶原、促胃液素对胃癌的诊断价值  

Clinical Significance of Serum Pepsinogen,Gastrin Levels in Gastric Cancer

作　　者：刘家云[1] 陈名声[1] 苏明权[1] 于文彬[1] 郝晓柯[1] 

机构地区：[1]第四军医大学西京医院检验科,陕西西安710032

出　　处：《现代检验医学杂志》2007年第3期19-21,共3页Journal of Modern Laboratory Medicine

摘　　要：目的研究血清胃蛋白酶原Ⅰ(PG I)、胃蛋白酶原Ⅱ(PGⅡ)及促胃液素(GS)与胃癌发生的关系,探讨检验血清PGⅠ,PGⅡ,GS对胃癌的诊断价值。方法采用免疫放射分析法(IRMA)和放射免疫分析法(R IMA)检测36例胃癌患者、23例胃良性病、11例萎缩性胃炎和34例正常人血清蛋白酶原、促胃液素水平并进行比较。结果胃癌患者血清PGⅠ,PGⅡ的水平显著低于胃良性病和正常人组(P<0.05),而血清GS水平显著高于胃良性病和正常人组(P<0.05),其中不同分化程度间差异不明显(P>0.05),术后血清PGⅠ,PGⅡ,GS水平显著低于术前水平(P<0.05),复发组的水平显著高于术后未复发组(P<0.05)。结论检测血清PGⅠ,PGⅡ,GS对胃癌的诊断及区别胃良性病具有较高的临床价值。Objective To evaluate the relationship between serum pepsinogen（PG）,gastrin（GS）level and gastric cancer,to study clinical significance of detecting serum PG,GS in patients with gastric cancer. Methods Immunoradiometric assay （IRMA）and radio-immunity metric assay（RIMA）were used to detect serum PG and GS in 36 patients with gastric cancer, 23 patients with benign stomach diseases, 11 patients with atrophic gastritis and 34 healthy control. Results The levels of PG I and PG I in gastric cancer were significantly lower than those in benign stomach diseases and control group（P〈0.05） ,but the levels of gastrin were significantly higher than those（P〈0.05） ,however there was no significantly distinction between different degrees of differentiation. The levels of PGⅠ ,PG Ⅱand GS in post-operation group were significantly lower than those in pre-operation（P（0.05）,the levels of PGⅠ ,PG Ⅱ and GS in post-operation repea group were significantly higher than those in non-repea group （P（0.05）. Conclusion Detection of serum pepsinogen and gastrin is significant to diagnosis and discrimination of patients with gastric cancer ,stomach benign diseases.

关 键 词：胃癌 胃蛋白酶原 促胃液素 放射免疫分析 

分 类 号：R730.43[医药卫生—肿瘤] R735.2[医药卫生—临床医学]