氨基胍对STZ糖尿病大鼠视网膜微血管病变的影响  

Influence of aminoguanidine on retinal microvascular pathological changes in diabetic rats

作　　者：庞东渤[1] 符丽娟[2] 

机构地区：[1]辽宁医学院附属第一医院眼科,中国辽宁省锦州市121001 [2]辽宁医学院药理教研室,中国辽宁省锦州市121001

出　　处：《国际眼科杂志》2007年第3期675-676,共2页International Eye Science

基　　金：中国辽宁省自然科学基金资助(No.002114)~~

摘　　要：目的:观察STZ糖尿病大鼠视网膜微血管病理改变及氨基胍对微血管病变的影响。方法:制备STZ糖尿病大鼠动物模型,随机分为正常对照(CON)组、糖尿病3mo(DM3)组,6mo(DM6)组,氨基胍3mo(AG3)组和6mo(AG6)组。每组大鼠各10只,分别饲养3,6mo。取大鼠视网膜进行视网膜微血管形态及超微结构观察。结果:DM组视网膜周细胞数目随病程逐渐减少,细胞核染色质浓缩,边集,分布于核膜下;胞质内线粒体肿胀,变性,空泡化,胞质消失,基底膜增厚。AG治疗组则明显改善。结论:氨基胍对STZ糖尿病大鼠视网膜微血管病变有防治作用。AIM：To observe pathological changes of retinal microvo ascular in diabetic rats and contribution of aminoguanidine. METHODS： Animal models of were induced by streptozotocin and randomly divided into diabetic mellitus （DM3） group, DM6 group, aminoguanidine （A（33）group, A（36 group and control group. The rats were killed after 6 months, their retinas were studied by light and electronic microscope. RESULTS： In DM group, the number of pericyte decreased and chromatin nucleolus concentrated, mitochondrion swelled and denaturalized, basement membrane thickened. The pathological changes of retina were improved in DM group. CONCLUSION： Aminoguanidine can effectively prevent and cure the damages of retinal capillary in stz-diabetic rats.

关 键 词：糖尿病视网膜病变 氨基胍 大鼠 

分 类 号：R774.1[医药卫生—眼科]