它莫西芬对子宫内膜血管内皮生长因子表达的影响  

The Variety of Vascular Endothelial Growth Factor Expression in Endometrium of Tamoxifen User

作　　者：杨保军[1] 邢凤玲[1] 冯力民[1] 张华[2] 孙海梅[2] 

机构地区：[1]首都医科大学附属北京天坛医院妇产科 [2]首都医科大学基础医学院组织胚胎学教研室

出　　处：《首都医科大学学报》2007年第3期412-414,共3页Journal of Capital Medical University

摘　　要：目的探讨乳腺癌术后服用它莫西芬后子宫内膜的分子生物学变化。方法用免疫组织化学LSAB法检测血管内皮生长因子(VEGF)在服用它莫西芬2年以上绝经后乳腺癌患者的子宫内膜组织和子宫内膜腺癌组织的表达变化,以脱垂子宫的子宫内膜为对照组。结果服用它莫西芬后绝经后乳腺癌患者VEGF的表达在子宫内膜与子宫内膜腺癌组织差异无统计学意义(P<0.05),但与脱垂组子宫内膜比差异有统计学意义(P<0.05);服用它莫西芬后子宫内膜VEGF免疫组化染色较深。结论它莫西芬对绝经后子宫内膜的弱雌激素作用可上调子宫内膜VEGF的表达,影响子宫内膜的微血管生成,可能与子宫内膜病理学改变有关。Objective To investigate the bimolecular effects of tamoxifen on the uterine endometrium in women with breast cancer. Methods Using immunohistochemistry（LSAB） on formalin-fixed paraffin-embedded endometrial sections to study the variety of vascular endothelial growth factor（VEGF） in endometrium of postmenopausal patients with breast carcinoma who took tamoxifen more than two years and in endometral adenocarcinoma, with prolapse uterine endometrium as normal controls Results The VEGF staining indices were significantly higher in endometrium of tamoxifen user and endometrial adenocarcinoma than in controls （P 〈 0.05 ）. The VEGF in the endometrium tamoxifen user was markedly increased, as much as that of endometrial adenoearcinoma. Conclusion The High-score of VEGF expression of the endometrium in women who have been treated with tamoxifen for breast cancer may be correlated with tamoxifen, which as the mechanism of oestrogen and anti-oestrogen action has the ability to affect the endometrium angiogenesis. Tamoxifen is able to induce pathological changes in endometrium.

关 键 词：血管内皮生长因子 子宫内膜癌 它莫西芬 

分 类 号：R737.3[医药卫生—肿瘤]