药物致伪膜性肠炎969例回顾分析  

Review on 969 Cases of Antibiotics Related Pseudomembranous Enterocolitis

作　　者：张俊虎[1] 王杰松[1] 刘刚[1] 王海涛[1] 李勉珊[1] 

机构地区：[1]解放军第306医院药学部,北京100101

出　　处：《抗感染药学》2007年第2期95-97,共3页Anti-infection Pharmacy

摘　　要：目的:通过对抗生素所致伪膜性肠炎研究,分析其成因及治疗与预后的因素,总结临床经验教训,提高诊治水平。方法:回顾分析1994～2005年中国国内公开报道的969例伪膜性肠炎患者的用药及临床情况。结果:患者均为使用抗生素或抗癌药物过程中出现腹泻、腹痛等表现。抗生素种类与头孢菌素和喹诺酮类最为密切。结论:伪膜性肠炎多在应用抗生素后发病,抗生素应用不合理是引起伪膜性肠炎的主要原因,老年人、重病患者及外科大手术患者为易感人群。在临床抗感染治疗过程中。Objective： Antibiotics related pseudomembranous enterocolitis was studied by analysis of etiopathogenesis,treatment and prognosis,and lessons were learned to improve the level of diagnosis and treatment. Methods： Data collected from 969 case of pseudomembranous enterocolitis published in civic documents were reviewed. Death rate, death number, gender and age were retrieve and statistics. Results： All patients have diarrhea on the course of administering antibiotics, most of which are cephalosporin and qui- nolone. Conclusions： pseudomembranous enterocolitis often happen after antibiotics was used and the evident cause is irrational use of antibiotics. The aged, the severe illed patients just passing large surgery were susceptible population, In the course of antifection use of antibiotics, the rational use of antibiotics should be very careful to prevent the happening ofpseudomembranous enterocolitis.

关 键 词：伪膜性肠炎 抗生素 去甲万古霉素 

分 类 号：R574.5[医药卫生—消化系统]