广东地区近20年急性胰腺炎的发病率及病因分析  

Analysis on etiology of acute pancreatitis during the past 20 years in Guangdong province.

作　　者：黄开红[1] 林萍[2] 聂胜利[2] 刘建化[1] 王凌云[1] 陈其奎[1] 朱兆华[1] 

机构地区：[1]中山大学附属第二医院消化内科,广州 510120 [2]广东省人民医院消化内科

出　　处：《胰腺病学》2007年第3期140-143,共4页Chinese JOurnal of Pancreatology

基　　金：国家自然科学基金项目（30670951）;广东省自然科学基金项目（06021322）;广州市科技攻关项目（2003Z3-E0381）;广东省科技攻关项目（20051331211002）

摘　　要：目的观察广东地区不同时间段AP的发病率和病因谱的变化。方法总结分析中山大学附属第二医院及广东省人民医院1986年至2005年1316例AP住院患者的临床资料，将20年资料按每5年为一年度段进行统计分析。结果1986年至1990年间AP病例数占同期内外科住院总人数的0．19％，1991年至1995年间上升为0．36％，1996年至2000年间升至0．54％，而2001年至2005年间则高达0．71％，差异有显著性意义（P〈0．05）。按病因分析，4个年度段胆源性胰腺炎分别占65．97％，62．81％，59．15％，58．65％（P〉0．05）；高脂血症相关AP分别占6．25％，10．88％，12．96％，14．66％（P〈0．05）；特发性胰腺炎分别占4．86％，8．77％，10．42％，12．59％（P〈0．05）。高脂血症相关AP和特发性胰腺炎所占比例呈上升趋势，而胆源性胰腺炎则略呈下降趋势。结论AP发病例数逐年增多，胆道疾病仍为主要病因，高脂血症升为第2位原因，其次为特发性胰腺炎。Objective To investigate the changes in incidence and etiologies of acute pancreatitis in different time periods in Guangdong province. Methods 1 316 patients with acute pancreatitis were admitted to the Second Affiliated Hospital of Sun Yat-sen University and the Guangdong Provincial People＇s Hospital. The time from 1986 to 2005 was divided into four 5-year groups and we reviewed the clinical data to analyze the etiology of acute pancreatitis. Results The percentage of AP patients in all the patients admitted to the hospitals among 1986 - 1990, 1991 - 1995, 1996 - 2000, 2001 - 2005 year were 0.19%, 0. 36 %, 0.54%, 0.71%, respectively, with significant differences （P 〈 0. 05 ）. The incidence of biliary tract diseases among four 5-year groups were 65.97%, 62.81%, 59.15%, 58. 65%, respectively （P 〉 0.05）; the incidence of hyperlipidemia were 6. 25%, 10. 88%, 12. 96%, 14. 66% （P 〈 0. 05 ）, respectively; the incidence of idiopathic pancreatitis were 4. 86%, 8. 77%, 10. 42%, 12. 59%, respectively （P 〈 0.05）. Conclusions The incidence of AP increased in the recent 20 years, and biliary tract disease was the predominant etiology, hyperlipidemia was the second most common etiology, followed by idiopathic pancreatitis.

关 键 词：胰腺炎 急性病 数据收集 病因学 

分 类 号：R57[医药卫生—消化系统]