人乳头状瘤病毒负荷量与宫颈上皮内瘤变关系的初步研究  

Preliminary study on the relationship between loads of human papilloma virus and cervical intraepithelial neoplasia

作　　者：张天锋[1] 郭广洲[1] 曾秀华[1] 许学岚[1] 黄志欣[1] 

机构地区：[1]深圳市罗湖医院妇产科,广东深圳518001

出　　处：《临床和实验医学杂志》2007年第6期72-73,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的 探讨人乳头状瘤病毒（HPV）负荷量与子宫颈上皮内瘤变（CIN）的关系。方法分析2005年12月至2006年12月我院门诊因HPV检查阳性，行液基细胞学检查（LCT），阴道镜活检者105例。结果 子宫颈上皮内瘤变（CINⅠ～Ⅲ）的HPV—DNA含量明显高于子宫颈炎，差异有显著性（P〈0．05）。不同级别的子宫颈上皮内瘤变（CINⅠ～Ⅲ）的HPV—DNA含量呈递增超势，但差异无显著性（P〉0.05）。结论HPV—DNA含量随宫颈病变的严重程度而增加，可作为宫颈癌前病变及宫颈癌的筛查及病情追踪监测的一项客观指标。Objective To investigate the relationship between loads of human papilloma virus （HPV） and cervical intraepithelial neoplasia （CIN）. Methods High risk types of HPV infection was screened with hybrid capture Ⅱ （ HC Ⅱ ） in 105 patients from Dec. 2005 to Dec. 2006. Those with positive HPV further underwent colposcopy and multifocal directed punch biopsies plus endocervical curettage. Results HPV - DNA loads were significantly higher in women with CIN Ⅰ, CIN Ⅱ and CIN Ⅲ than those with cervicitis （ P 〈0.05） , but there were no significant differences among three groups（ P 〉 0.05 ） . Conclusions Viral loads of HPV - DNA increase with severity of cervical neoplasia. So it could be used in screening primary cervical carcinoma.

关 键 词：人乳头状瘤病毒 病毒负荷量 宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤]