原发性肝癌的CT血供分型与VEGF相关性  

MSCT Feature of Tumor Blood Supply Type in Patients with Hepatocellular Carcinoma:Correlation with Serum Vascular Endothelial Growth Factor(VEGF)

作　　者：李运成[1] 王群兴[2] 谭光喜[1] 向希映[2] 鲁际[2] 曾志华[2] 李丽亚[2] 张晓磷[2] 宋浩[2] 

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443003 [2]宜昌市中心人民医院

出　　处：《肿瘤防治研究》2007年第6期446-448,共3页Cancer Research on Prevention and Treatment

摘　　要：目的检测肝细胞癌(Hepatocellular carcinoma,HCC)患者血清血管内皮细胞生长因子(vascu-lar endothelial growth factor,VEGF)水平与HCC血供分型的关系。方法根据多层螺旋CT(multislice helical computed tomography,MSCT)增强扫描时病灶的强化特点分为肝动脉、肝动脉加门静脉、少血供等不同血供类型HCC患者60例;采用酶联免疫吸附(ELISA)法检测20例健康人和60例HCC患者血清中的VEGF水平,并将HCC血供类型与血管内皮细胞生长因子(VEGF)水平的相关性作统计学分析。结果20例肝动脉血供HCC患者血清中VEGF含量及20例门静脉与肝动脉双重血供HCC患者VEGF水平明显高于少血供和健康人群(P<0.01);20例少血供HCC患者VEGF水平与健康人群无明显差异(P>0.05)。结论HCC患者的CT不同血供类型与血清VEGF水平有关,可为HCC介入治疗方案的制定提供帮助。Objective To study the correlation between the multislice helical CT（MSCT） feature of tumor blood supply type in patients with hepatocellular carcinoma（HCC） and the serum level of vascular endothelial growth factor（VEGF）. Methods According to the contrast-enhanced characteristic of lesion on MSCT, the tumor blood supply in 60 patients with HCC were classified into different types such as arterial blood supply, portal blood supply, arteroportal blood supply, and poorly blood supply. Enzyme linked immunosorbent assay （ELISA） was used to test the serum levels of VEGF collected from 20 healthy individuals and 60 patients with HCC respectively. At last, the CT features of tumor blood supply type were performed statistical analysis with the serum levels of VEGF. Results The serum levels of VEGF in 20 patients with arterial blood supply type and 20 patients with arteroportal blood supply were significantly higher than that in 20 healthy individuals and 20 patients with portal blood supply or poorly blood supply type （P〈0. 01） . There was no statistical significance of serum VEGF levels between 20 patients with portal blood supply or poorly blood supply type and 20 healthy individuals（P〉0.05）. Conclusion The pattern of tumor blood supply for HCC on MSCT is correlative with the serum level of VEGF, and it is of great value in the interventional therapy for HCC.

关 键 词：肝细胞癌 血供分型 血管内皮细胞生长因子 断层摄影术 X线计算机 

分 类 号：R735.7[医药卫生—肿瘤]