精神分裂症9号染色体基因扫描研究  

A screen study for genetic loci associated with schizophrenia on chromosome 9

作　　者：朱海宁[1] 陈刚[1] 温晓燕[1] 林汝湘[1] 朱建平[2] 魏然[1] 周鹏[1] 栾萌[1] 于锡巧[1] 高春义[1] 翁正[3] 

机构地区：[1]山东省医学科学院基础医学研究所现代医用药物与技术重点实验室,济南250062 [2]山东潍坊市第三人民医院 [3]山东省精神卫生中心防治科

出　　处：《临床精神医学杂志》2007年第3期151-153,共3页Journal of Clinical Psychiatry

基　　金：国家自然科学基金资助项目(30440042);国家863资助项目(2002AA223021);山东省自然科学基金重点项目(Z2004C10)

摘　　要：目的:对山东半岛精神分裂症患者及正常对照者的9号染色体进行基因扫描,查找精神分裂症的关联位点。方法:在9号染色体上间隔10cM(厘摩)遗传距离,选择20个微卫星遗传位点,用脱氧核糖核酸(DNA)混合池的方法对119例精神分裂症患者与119名正常对照者的DNA样本分别混合后进行基因扫描,对比患者组与对照组在差异位点的等位基因峰型比率的差异。结果:在D9S273遗传位点患者组与对照组的等位基因频率差异有统计学意义(P<0.01)。结论:山东半岛东部地区精神分裂症患者群体中存在与9号染色体关联的区域。Objective： Patients with schizophrenia and normal controls in Shangdong peninsula were mapped on chromosome 9 to look up the associated genetic loci related to schizophrenia, Method：20 microsatellite markers on chromosome 9 were selected by every genetic spacing of 10 cM. Mixed 119 samples of patients with schizophrenia and 119 samples of normal controls for gene scan in DNA pooling. Statistic analysis was performed to compare the difference in the frequency of each allele between the two group samples, Results： There was a significant difference at genetic locus D9S273 between the two groups （ P 〈 0.01 ）. Conclusion： Patients with schizophrenia in Shandong peninsula have related genetic loci on chromosome 9.

关 键 词：精神分裂症 染色体 遗传 基因 

分 类 号：R749.3[医药卫生—神经病学与精神病学]