帕罗西汀治疗2型糖尿病伴抑郁的研究  

Clinical observation on type 2 diabetes mellitus accompanied with depression treated by paroxetine

作　　者：宋兵福[1] 伍毅[1] 陈一郡[1] 冯绮文[2] 全彩娟[3] 徐勤燕 

机构地区：[1]上海市杨浦区精神卫生中心,200090 [2]上海市新华医院 [3]上海市中山医院青浦分院 [4]上海市安亭医院

出　　处：《临床精神医学杂志》2007年第3期181-182,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨帕罗西汀对2型糖尿病伴发抑郁患者生活质量的影响。方法:对45例2型糖尿病伴发抑郁患者给予帕罗西汀治疗。疗程12周。治疗前后分别进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)及健康状况调查问卷(SF-36)评定。对照组50例为不伴抑郁的糖尿病患者进行SF-36评定。结果:帕罗西汀能明显改善治疗组抑郁、焦虑症状;治疗前2型糖尿病伴抑郁患者生活质量明显低于对照组。结论:帕罗西汀能明显改善2型糖尿病伴抑郁患者的生活质量及预后。Objective：To explore the quality of life in patients with type 2 diabetes mellitus accompanied with depression treated by paroxitine. Method： Forty-five type 2 diabetes mellitus patients accompanied with depression were treated by paroxetine for 12 weeks. Hamilton depression scale （HAMD）, Hamilton anxiety scale （HAMA） and the medical outcomes study 36 item short form health survey （SF-36） were used before and after treatments. 50 controis were evaluated with SF-36. Results：Paroxetine significantly improved the symptoms of depression and anxiety in type 2 diabetes mellitus with depression. Quality of life in patients with type 2 diabetes mellitus accompanied with depression was significantly lower than that in controls before treatment. Conclusion： Paroxetine can significantly improve the quality of life and prognosis in patients with type 2 diabetes mellitus accompanied with depression.

关 键 词：帕罗西汀 2型糖尿病 抑郁 生活质量 

分 类 号：R749.053[医药卫生—神经病学与精神病学]