pH敏感含糖三元共聚水凝胶Poly(AM-CO-IA-VBG)的药物释放性能研究  

The Drug Release Properties of Poly(acrylamide-co-itaconate-vinylbenzylglycosylallylamide )Hydrogels

作　　者：席延卫[1] 李凌冰[1] 谭业邦[2] 胥振芹[2] 李英 

机构地区：[1]山东大学药学院药物药剂所,济南250012 [2]山东大学化学与化工学院,济南250100 [3]山东省日照市东港区人民医院,日照276800

出　　处：《生物医学工程学杂志》2007年第3期603-606,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(29904003);山东大学预研基金资助项目(21310051310081)

摘　　要：用4-乙烯基苄基胺与葡萄糖内酯反应合成了4-乙烯苄基葡萄糖酰胺单体(VBG)。以亚甲基双丙烯酰胺(BisA)为交联剂,用过硫酸钾(KPS)引发丙烯酰胺(AM)、衣康酸(IA)及4-乙烯苄基葡萄糖酰胺使之共聚,得到pH敏感含糖结构的三元共聚水凝胶。用核磁共振及红外光谱对单体和水凝胶的结构进行了表征,研究了不同水凝胶中药物的释放性能,以及pH值及盐的浓度对水凝胶中药物释放的影响。结果表明:水凝胶中药物在低pH值时或盐中药物释放显著下降,表明水凝胶对酸或盐有强烈的响应性。Sugar-containlng monomer vinylbenzylglycosylallyamide （VBG）was synthesized by vinylbenzyl amine and δ-gluconolactone in dimethylformamide （DMF） solution. The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG, itaconic acid （IA） and acrylamide （AM）. The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively. The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation. The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration.

关 键 词：PH敏感 水凝胶 含糖 释药特性 

分 类 号：R318.08[医药卫生—生物医学工程]