左氧氟沙星、阿莫西林、埃索美拉唑三联疗法在幽门螺杆菌补救治疗的临床研究  

The Study of Levofloxacin,Amoxicillin and Esomepazole triad system as rescue therapy for Helicobacter pylori infection

作　　者：粱志根[1] 全华斌[1] 何善智[1] 

机构地区：[1]广东省中山市人民医院消化内科,广东中山528403

出　　处：《海南医学》2007年第7期1-3,共3页Hainan Medical Journal

摘　　要：目的探讨左氧氟沙星、阿莫西林、埃索美拉唑三联疗法在幽门螺杆菌(H.Pylori)补救治疗中的疗效及安全性。方法将72例经克拉霉素、阿莫西林、埃索美拉唑三联1周疗法根除治疗后4周,胃镜胃窦部快速尿素酶试验(RUT),14C-尿素呼气试验(14C-UBT)仍阳性的患者随机分为两组:试验组38例,应用左氧氟沙星0.2克,每日2次;阿莫西林1.0g,,每日2次,埃索美拉唑40mg,每日1次,10天;对照组34例,应用胶体果胶铋200mg,每日2次,呋喃唑酮0.2g,每日2次,四环素1.0g,每日2次,埃索美拉唑40mg,每日1次,14天。四周后复查14C-UBT。结果14C-UBT转阴:试验组33例,86.8%,明显高于对照组22例,64.7%,两组比较差异显著(p<0.05)。副作用发生率,试验组2例,5.2%,对照组10例,29.4%,主要表现为:恶心、呕吐、腹痛、腹泻、乏力,后者明显高于前者(p<0.01),且6例需加用其他药物对症治疗。结论左氧氟沙星、阿莫西林、埃索美拉唑三联疗法在H.Pylori初次根除失败的补救治疗中较铋剂加呋喃唑酮、四环素、埃索美拉唑四联疗法疗效高,副作用少。Objective The aim was to probe the efficacy and tolerability of levofloxaein, amoxieillin and esomepazole triad system as rescue therapy for Helicobacter pylori infection. Methods 72 patients had been eradicated Helieobaeter pylori （HP）one week with elarithromyein, amoxieillin and esomepazole triad system ,four weeks later, from ^14C-urea breath test （^14C -UBT）, rapid urease test in gastroseopy on gastric antrum, who still were positive phase. All of them randomly chose into two groups： 38 patients who were test group, treated levofloxaein 0.2g （twice a day）, amoxieillin 1.0g, （twice a day）, esomepazole 40mg （once a day）, the course of treatment were10 days;34 patients who were compare group, treated colloidal bismuth pectin （CBS） 200mg （twice a day）, Furazolidone 0.2g （twice a day）, tetracyeline1.0g （twice a day）, esomepazole 40rag （once a day）. The course of treatment were 14 days. After four weeks, HP status was assessed by ^14C-UBT. Results There were 33 subjects eradicated in test group and 22 eradicated in compare group. The eradication rates 86.8% of test group were higher strikingly than that 64.7% of compare group （p〈0.05）. The Side-effect rate, 2 patients in test group of 5.2%, 10 patients in compare group of 29.4%. main expression, nausea, vomiting, abdominal pain, diarrhea, tired, compare group was higher than test group （p〈0.01）,and 6 patients must treat with other medicine. Conclusions levofloxacin, amoxicillin and esomepazole triad system as rescue therapy for Helicobacter pylori is better than CBS, furazolidone, tetracycline, esomepazole quadruple regimen is an effective and safe rescue therapy after a failed first-line triple therapy .

关 键 词：左氧氟沙星 幽门螺杆菌 根除 补救治疗 

分 类 号：R573[医药卫生—消化系统]