经单鼻孔-蝶窦入路显微手术切除垂体腺瘤临床研究(附138例报告)  

Clinical study on the microsurgical resection of pituitary adenomas via the mononostril-septumtranssphenoidal approach:a report of 138 cases

作　　者：张修宝[1] 宁波[1] 王国军[1] 张明然[1] 

机构地区：[1]山东省泰安市中心医院神经外科,271000

出　　处：《中华神经医学杂志》2007年第6期619-620,623,共3页Chinese Journal of Neuromedicine

摘　　要：目的探讨经鼻中隔蝶窦入路显微手术切除垂体腺瘤的疗效。方法回顾分析我院自1998年1月至2005年6月共138例采用经单鼻孔-蝶窦入路显微手术治疗垂体腺瘤的临床资料。结果每例手术时间60～120 min,平均80 min。123例(89.1%)肿瘤全切。19例尿崩,12例颅内感染,无出血、死亡等并发症的发生。136例患者术后随访3～12个月。激素分泌过高、视野障碍、闭经等症状均有不同程度的改善。结论经单鼻孔手术可安全有效地治疗绝大部分垂体腺瘤。Objective To evaluate the effectiveness of the microsurgical resection of pituitary adenomas via the mononostril-septum-transsphenoidal approach. Methods The clinical data of 138 consecutive patients undergoing microsurgical mononostril resection of their pituitary adenomas at our department from Jan. 1998 to Jun. 2005 were included in our retrospective study. Results Each operation was around 60-120 min, the average operating time being 80 min, and the total resection rate was 89.1% （123 cases）. A total of 19 patients suffered from diabetes insipidus and 12 patients suffered from intracranial infection. No hemorrhage or death occurred to the total 138 consecutive patients. The follow-up study for 136 patients lasting for 3 to 12 months showed that improvement occurred to abnormally high secretion of hormone, visual impairment and amenorrhea etc to a certain extent. Conclusion The mononostril-septum-transsphenoidal microsurgery is an effective and safe therapy for the resection of most pituitarv adenomas.

关 键 词：垂体腺瘤 经单鼻孔—蝶窦入路 显微外科手术 

分 类 号：R736.4[医药卫生—肿瘤]