肝癌组织中Glut1与HIF-1α表达的关系及临床意义  

Relation between Glut1 and HIF-1α expression in human hepatocellular carcinoma and their clinical significance

作　　者：梁辉[1] 窦科峰[1] 

机构地区：[1]第四军医大学西京医院,陕西西安710032

出　　处：《山东医药》2007年第16期5-7,共3页Shandong Medical Journal

摘　　要：目的探讨肝细胞癌组织中葡萄糖转运蛋白1(Glut1)和缺氧诱导因子1α(HIF-1α)的表达情况及其临床意义,并分析两者的相关性。方法用免疫组织化学Envision法检测45例肝细胞癌、11例正常肝组织中的Glut1和HIF-1α表达情况。结果Glut1和HIF-1α在肝癌组织中的阳性率明显高于正常肝组织(P<0.05)。在肝癌组织中,Glut1和HIF-1α表达均与肿瘤大小、临床分期、有无淋巴结转移、有无门静脉癌栓有关(P<0.05)。肝癌组织中Glut1与HIF-1α表达呈正相关(r=0.583,P<0.01)。结论Glut1和HIF-1α异常表达与肝癌的发生、发展有一定关系。HIF-1α可能通过上调Glut1表达促进肝细胞癌发生。[Objective] To investigate the expression and clinical significance of Glut1 protein, HJF-1α protein in human hepatocellular careinoma（HCC）, and analyze their correlation. [Methods] Immunohistochemical staining Envision method was used to detect the expressions of Glut1 and HIF-1α in 45 cases of human hepatocellular carcinoma, 11 cases of normal hepatic tissue. [Results] The positive expression rates of Glut1 and HIF-1α in human hepatocellular carcinoma were significantly higher than those in normal hepatic tissue （P〈0.05）. There was association between the expressions of Glut1, HIF-1α and tumor size, clinical stage, lymphatic metastasis and portal vein cancer-embolus （P〈0. 05）. With the increase of expression of Glutl,the expression of HIF-1α was increased; Positive correlation was found between Glut1 and HIF-1α expression （r= 0. 583,P〈0. 01）. [Conclusion] The abnormal expression of Glut1 and HIF-1α in human hepatocellular carcinoma may contribute to the pathogenesis and development of the hepatoma. HIF-1α may promote the genesis of hnman hepatocellular carcinoma by up-regulatulating Glut1 expression.

关 键 词：癌 肝细胞 葡萄糖转运蛋白1 缺氧诱导因子1Α 免疫组织化学 预后 

分 类 号：R735.7[医药卫生—肿瘤]