冠心Ⅱ号方单煎与合煎对主要有效成分的影响  

Effect of the Two Kinds of Decocting Methods on Contents of Main Active Components in Guanxin Ⅱ Decoctions

作　　者：仝燕[1] 王锦玉[1] 冯伟红[1] 闫家福[1] 王智民[1] 朱晓新[1] 李连达[2] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院西苑医院

出　　处：《中国实验方剂学杂志》2007年第6期24-26,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家973项目-冠心Ⅱ号配伍规律研究(2005CB523400)

摘　　要：目的:探讨冠心Ⅱ号方单煎与合煎对主要有效成分的影响。方法与结果:对单煎与合煎样品中多成分进行全面考察,君药丹参与川芎、赤芍、红花、降香分别合煎,丹酚酸B的提出量均高于丹参单煎,而全方合煎丹酚酸B的煎出量最高;赤芍中芍药苷与丹参的情况相似,合煎含量明显提高;川芎及红花与丹参合煎或全方合煎,指标成分阿魏酸、羟基红花黄素A含量均较单煎有所下降。结论:冠心Ⅱ号方全方合煎不等于各药单煎的混合,合煎液中丹酚酸B是含量明显高于单煎,与药效试验全方作用超过单味药的相加结果一致。Objective：To compare the contents of the main active components in Guanxin Ⅱ Decoctions（GX- Ⅱ ） which were decocted with different ways. Methods：The five ingredients in the formula were decocted in 8 modes, ie, decocting singlely, decocting two in 4 different combinations, and decocting all ingredients together. The contents of the active components in different decoctions were determined by HPLC methods. Results： The predominant ingredient, Danshen Root, in this formula was decocted with other four ingredients（Szechwan Lovage Rhizoma, Safflower, Red, Peony Root and Rose Wood） respectively. The extract rates of salvianolic acid B in the above four decoctions were higher than that of Danshen Root decoction. And the extract rates of salvianolic acid B was the highest in the decoction that five ingredients in this formula were decocted together. The extract rates of paeoniflorin in decoctions were similar with that of salvianolic acid B. But the rates of ferulic acid and hydroxymethyl safflower yellow A were contrary to that of the other two active components. When Szechwan Lovage Rhizome or Rosewood was decocted with other, ingredients, the extract rates of feralic acid and hydroxy-methyl safflower yellow were low. Conclusions： The contents of the active components in the decoction（ Ⅰ ） which was decocted with all ingredients together were not equal to that of mixed decoctions（ Ⅱ ） which were decocted with each ingredient separately. The results of pharmacological tests showed that the effects of the decoction （ Ⅰ） were better than that of the mixed decoctions（ Ⅱ ）.

关 键 词：冠心Ⅱ号 煎煮方法 丹酚酸B 芍药苷 阿魏酸 

分 类 号：R283.6[医药卫生—中药学]