CYBA基因多态性与高血压病相关性的研究  

Correlation Study Between CYBA Gene Polymorphism and Essential Hypertension

作　　者：王兵[1] 袁晓[1] 王晓春[1] 

机构地区：[1]中南大学湘雅医学院医学检验系,湖南长沙410013

出　　处：《实用预防医学》2007年第3期623-624,共2页Practical Preventive Medicine

基　　金：湖南省科技项目(05SK3035)

摘　　要：目的探讨CYBA基因C242T多态性与高血压病的关系。方法应用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)检测120例高血压病患者和120例健康者CYBA基因C242T多态性。结果高血压病组CC基因型频率为0.68,高于正常对照组CC基因型频率0.53(χ2=5.035,df=1,P=0.034)。高血压病组C等位基因频率为0.84,正常对照组C等位基因频率为0.77,两组无显著性差异(χ2=3.793,df=1,P=0.066)。结论CYBA基因C242T多态性与高血压有明显相关性,T等位基因可能是高血压病保护因素。Objective To investigate the relationship between CYBA gene 0242T polymorphism and essential hypertension. Method The CYBA gene 0242T polymorphism was detected in 120 patients with essential hypertension and 120 healthy control subjects by POR - RFLP. Results The CO genotype frequency 0.68 in patients with hypertension was higher than the healthy controls 0.53 （X^2 =5.035, df= 1, P = 0. 034）. C allele frequency was 0.84 in patients with hypertension and 0.77 in healthy controls, which showed no significant difference between these 2 allele frequencies distribution （X^2 = 3. 793, df = 1, P = 0. 066）. Conclusion The CYBA C242T gene polymorphism closely relates to essential hypertension. T allele may be a protective factor of hypertension.

关 键 词：高血压病 基因多态性 CYBA 

分 类 号：R544.1[医药卫生—心血管疾病]