亚甲基[6,6]-富勒烯[C_(60)]单羧酸的合成  

Synthesis of methano[6,6]fullerene[C_(60)]carboxylic acid

作　　者：倪瑾[1] 叶光明[2] 胡宏岗[3] 姜云云[3] 蔡建明[1] 吴秋业[3] 

机构地区：[1]第二军医大学海医系防原医学教研室,上海200433 [2]中国人民解放军第101医院药剂科,江苏无锡214000 [3]第二军医大学药学院有机教研室,上海200433

出　　处：《药学实践杂志》2007年第3期145-146,共2页Journal of Pharmaceutical Practice

基　　金：国家自然基金资助项目(30200069)

摘　　要：目的:探索用溴乙酸乙酯合成亚甲基[6,6]-富勒烯[C60]单羧酸。方法:用溴乙酸乙酯制备硫叶立德,再与富勒烯[C60]制得相应的富勒烯[C60]羧酸乙酯,水解其乙酯。结果与结论:通过核磁、红外等分析方法确证所合成的中间体和目标化合物,并且这条路线经济、切实可行,适合大规模制备。Objective ： To find good route of synthesizing methano [ C60 ] fullerene carboxylic acid by using bromoactate for preparing some valuable fullerene derivatives. Methods： Using bromoactate as starting material, ylide was prepared. Ylide and fullerene were used to produce the methano [ C60 ] fullerene carboxylate and hydrolyze it. Results and Conclusion： The intermediate and ultimate products synthesized can be confirmed as the objective by NMR and IR, the method is feasible and economical .

关 键 词：合成 富勒烯 硫叶立德 富勒烯[C60]单羧酸 

分 类 号：R914.5[医药卫生—药物化学]