含银无机抗菌剂加入树脂中对口腔常见细菌黏附影响的研究  

Study of Adherence of Normal Oral Bacteria on Polymethyl Methyacrylate Containing Silversupported Silicate Inorganic Antibacterial

作　　者：李罡[1,2] 陈治清[2] 吴兴惠[3] 肖晓蓉[2] 李艳红[1] 朱硃[2] 

机构地区：[1]昆明医学院口腔医学院 [2]口腔生物医学工程教育部重点实验室,四川大学,四川成都610041 [3]云南大学材料科学与工程学院

出　　处：《华西口腔医学杂志》2007年第3期280-284,共5页West China Journal of Stomatology

基　　金：国家"十五"863资助项目(2002061006)

摘　　要：目的检测含银硅铝酸盐无机抗菌剂对口腔常见细菌的作用效果,以及加入该抗菌剂的基托树脂表面的口腔常见细菌的黏附情况。方法将一定量细菌、真菌接种到含有适当比例含银硅铝酸盐无机抗菌剂的培养基中,检测该抗菌剂的抑菌情况;应用体外菌斑模型观察含有抗菌剂的聚甲基丙烯酸基托树脂表面的微生物黏附状况。结果含银无机抗菌剂在8%的质量分数内可以完全抑制口腔常见细菌的生长,在质量分数为1.25%和2.50%的情况下能够有效地抑制牙龈卟啉单胞菌和白假丝酵母菌的生长;但是在16d的实验期内未能抑制细菌在材料表面的黏附。结论含银硅铝酸盐无机抗菌剂对口腔常见细菌有良好的抑菌效果,但是在聚甲基丙烯酸树脂材料中加入含银硅铝酸盐无机抗菌剂,没有表现出抑制细菌黏附的能力。Objective To study the oral normal bacteria adherence on polymethyl methyacrylate （PMMA） containing silver-supported silicate inorganic antibacterial, and the growth inhibitory concentration of silver-supported silicate inorganic antibacterial to normal oral bacteria were also investigated. Methods A certain volume of normal oral bacteria was inoculated on the Bill plate containing different dilution of silver-supported silicate inorganic antibacterial, then the growth of the bacteria was investigated by light microscope and biochemical methods; the oral bacteria plaque model in vitro was used to evaluate the adherence of d species normal oral bacteria mixture on the surface of PMMA which containing silver-supported silicate inorganic antibacterial in the proportion of 5% or 10%. Results The growth of normal oral bacteria was inhibited effectively by silver-supported silicate inorganic antibacterial within the concentration of 8%, and the growth of Porphyromonas gingivalis and Candida albicans were inhibited at concentration from 1.25% to 2.50%, but the PMMA containing silver-supported inorganic antibacterial could not prevent the adherence of bacteria within a period of 16 days. Conclusion Silver-supported silicate inorganic antibacterial has effectiveness on inhibiting the growth of normal oral bacteria, but could not prevent the adherence of oral normal bacteria mixture.

关 键 词：抗菌剂 银 聚甲基丙烯酸树脂 黏附 

分 类 号：R783.1[医药卫生—口腔医学]