人rδT淋巴细胞抗肿瘤特性的研究  

The Biological Characteristics of Human rδT Lymphocyte against Tumor Cells

作　　者：李新燕[1] 张学光[1] 谢炜[1] 朱学东[1] 

机构地区：[1]苏州医学院免疫学研究室

出　　处：《苏州医学院学报》1997年第1期1-3,197,共3页Acta Academiae Medicinae Suzhou

基　　金：国家卫生部"八五"科技攻关资助

摘　　要：分别采用4h51Cr释放法及3H—TdR掺入法检测人rδT淋巴细胞对各种肿瘤细胞的杀伤作用。结果显示：rδr细胞对XG—7、K562、Daudi、U937、Jurkat等肿瘤细胞株皆可介导高效杀伤作用；对自体及异体新鲜白血病细胞亦有明显的细胞毒效应；对正常的自体及异体淋巴母细胞却无明显的杀伤作用；同时，INF－α、IL－4等细胞因子可协同提高rδT细胞对肿瘤细胞的杀伤活性．In this paper the cytotoxicity of rδT cells against tumor cells was analysed by means of 51Cr- 4hreleasing and 3H-TdR incorporation assays. The result shows that rδT cells can mediate strong cytotocix activity to K562,Dandi,U937,XG-7 and freshly isolated autologous and allologous leukemia cells, but no cytotoxic activity to normal cells can be observed. Meanwhile interlukins such as IL- 4,TNFα Can enhance the Cytotoxiticy of rδT cells markedly. Therfore,rδT cells may have potential value for the tumor adoptive immunotherapy as one CTL.

关 键 词：rδT淋巴细胞 T淋巴细胞 抗肿瘤作用 

分 类 号：R73－36[医药卫生—肿瘤]