STAT蛋白在炎症性肠病发病机制中的作用  

The role of STAT proteins in the pathogenesis of inflammatory bowel disease

作　　者：牛宏垚[1] 张晓岚[1] 

机构地区：[1]河北医科大学第二医院消化内科,050000

出　　处：《国际消化病杂志》2007年第3期182-185,共4页International Journal of Digestive Diseases

摘　　要：炎症性肠病主要包括溃疡性结肠炎和克罗恩病,是肠道慢性非特异性炎症性疾病,病因尚不十分明确,近年来认为STAT蛋白,尤其是STAT3和STAT1通过细胞因子和JAK途径在炎症性肠病的发病机制中发挥重要作用,而SOCS家族参与STAT信号通路的负向调控。Ulcerative colitis （UC） and crohn disease （CD）, the two maior forms of inflammatory bowel disease （IBD） , are chronic intestinal diseases of nonspecific inflammation without precise etiopathogenisis. Recently, signal transducer and activator of transcription （STAT） family, especially STAT1 and STAT3 proteins are considered to play an important role in the pathogenesis of inflammatory bowel disease through cytokines and Janus tyrosine kinases （JAK） pathway. And suppressor of cytokine signaling （SOCS） is involved in the negative regulation of the STAT signaling pathway.

关 键 词：炎症性肠病 STAT蛋白 SOCS 

分 类 号：R574[医药卫生—消化系统]