长春西汀治疗血管性痴呆的临床疗效观察  

Vinpocetine in the treatment of vascular dementia

作　　者：韩锟[1] 贾宁[1] 闵连秋[1] 

机构地区：[1]辽宁医学院附属第一医院神经内科,辽宁锦州121001

出　　处：《脑与神经疾病杂志》2007年第3期205-206,共2页Journal of Brain and Nervous Diseases

摘　　要：目的:探讨长春西汀对血管性痴呆(VD)疗效和作用机制。方法:96例VD患者随机分成长春西汀治疗组和胞二磷胆碱对照组,分别在治疗第10、21d进行简易精神状态评分(MMSE)和长谷川评分(1DS),同时测定与记忆有关的乙酰胆碱酯酶(AchE)的活性。结果:长春西汀治疗组患者第21d的MMSE和IDS评分均高于治疗前和一般治疗组(P＜0．01),且长春西汀治疗组VD患者的乙酰胆碱酯酶(AchE)活性降低和血浆乙酰胆(Ach)含量升高(P＜0．05)。结论:长春西汀治疗VD疗效肯定,其机制可能与胆碱能神经系统功能增强有关。Objective： To explore the effect and therapeutic mechanism of Vinpocetine in treating vascular dementia. Methods： The score of MMSE , HDS and the activity of cholinergic system in 96 patients with VD were erected and compared with control group in 10 and 21 days respectively. Results： The scores of MMSE and HDS of vinpocetine group were significantly higher than those of common group. Vinpocetine could decrease the activity of cholinesterase and improve content of acetylcholine in plasm in 21 days. Conclusions： Vinpocetine has definite effect on VD , which may improve the function of cholinergic system.

关 键 词：长春西汀 血管性痴呆 胆碱能神经系统 

分 类 号：R743.9[医药卫生—神经病学与精神病学]