帕金森病血抗氧化系统变化及其临床意义  

The Changes of Blood Antioxidant System in Parkinson's Disease and Its Clinical Significance

作　　者：王佩珍[1] 郑锦志[1] 张佩利[1] 张扬达[1] 周君富[2] 

机构地区：[1]浙江医科大学附属第二医院神经内科,杭州310009 [2]浙江医科大学脑血管病研究室

出　　处：《中国神经免疫学和神经病学杂志》1997年第1期40-43,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：为探讨帕金森病（PD）患者体内抗氧化系统水平及其在PD发病中的作用，对70例PD患者血浆维生素C（P－VC）、维生素E（P－VE）、血浆及红细胞超氧化物歧化酶（P－SOD，E－SOD）、血浆与红细胞过氧化脂质（P－LPO，E－LPO）的水平进行了检测并与正常对照组比较。结果表明：PD组P-VC、P-VE水平及P-SOD、E-SOD活性均比正常对照组显著降低，而P-LPO、E-LPO则显著增高，并且P-VC、P-VE、E-SOD与病情和病程呈负相关，提示抗氧化系统缺陷及内源性氧自由基堆积与PD发病有密切关系。To explore blood levels of antioxidant system in patients with Parkinson's disease (PD)and its possible role in the pathogenesis of PD, plasma levels of vitamin E and vitamin C (P-VE, P-VC) and erythrocyte levels of superoxide dismutase (P-SOD, E-SOD) and lipoperox-ides (P-LPO, E-LPO) were measured in 70 PD patients, using 70 healthy volunteers as thecontrol group- The results showed that, levels of P-VE and P-VC as well as activity of P-SOD and E-SOD l0wered significantly as compared with the normal controls, while the con-tents of P-LPO and E-LPO were increased. ln addition, P-VE, P-VC and E-SOD levelswere inversely correlated with severity and duration of the disease. The results suggestedthat PD patients might have defects in antioxidant system, which could cause the accumula-tion of endogenous free radical and the degeneration of nigra neurons in the substantia nigra.

关 键 词：超氧化物岐化酶 脂质过氧化物 震颤麻痹综合征 

分 类 号：R742.5[医药卫生—神经病学与精神病学]