老年人药源性急性胃粘膜出血116例分析  

Analysis of Acute Gastric Mucosal Lesions Hemorrhage Induced by Drugs in 116 aged Patients

作　　者：沓世念[1] 梁鸿健[2] 

机构地区：[1]肇庆医学高等专科学校附属医院内科,广东肇庆526020 [2]肇庆市第一人民医院内科

出　　处：《药物流行病学杂志》2007年第3期161-162,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨老年人药源性急性胃粘膜出血的特点与防治对策。方法:对394例急性上消化道出血住院老年患者进行回顾性分析。结果:药源性急性胃粘膜病变出血患者116例,占29.4%。主要表现:黑便96.6%,呕血28.4%,上腹痛44.8%;内镜均见有不同程度的斑片状糜烂出血或/并浅表溃疡出血,多在高住胃体;相关药物:解热镇痛药81.0%,激素8.6%;既往有慢性胃病史者58.6%,空腹服药者62.9%。结论:老年人服用解热镇痛药、激素等药的机会较多,易致药源性急性胃粘膜病变,是老年人上消化道出血的重要原因之一。Objective： To study the patterns of drug induced acute gastric mucosal lesions hemorrhage in aged patients. Method： The study was based on retrospective review of 394 over 60 - year - old patients with upper gastrointestinal hemorrhage examined with endoscopy in 24 hours inthe hospital. Result： 29.4% hemorrhage resulted from drug induced acute gastric mucosal lesions. Their chief symptoms were that melena took up 96.6%, hematemesis, 28.4%, and abdominal pain, 44.8%. Its pathological appearances were plaque type erosion hemorrhage and/or superficial ulcer. 81.0% hemorrhage was caused by antipyretic analgesics, 8.6%, by glucocortisteroids, and 4.3%, by alcohol. 58.6% of the old patients had chronic gastric disease history. 62.9% took drugs when they were hungry. Conclusion： The use of singantipyretic analgesics and glucocortisteroids is very common in old people, and it is the important factor that results in gastric mucosal damage and hemorrhage. So it is necessary to pay more attention to the adverse drug reaction and rational use of drugs.

关 键 词：老年人 胃粘膜病变 急性药源性 药物不良反应 合理用药 

分 类 号：R573.2[医药卫生—消化系统]