食管腺癌和贲门癌鉴别诊断的研究进展  

The progress in discrimination between esophageal adenocarcinoma and cardia adenocarcinoma

作　　者：叶春荣[1] 王雯[1] 

机构地区：[1]福建医科大学福总临床医学院消化内科,福建福州350025

出　　处：《国际内科学杂志》2007年第6期330-334,共5页International Journal of Internal Medicine

基　　金：福建省青年科技人才创新项目;编号:2002J059

摘　　要：食管腺癌和贲门癌是临床上常见的上消化道恶性肿瘤,两者概念不同,又有重叠之处,特别是食管下段腺癌和贲门癌,临床上常需对两者进行鉴别诊断,以指导临床治疗和判断预后,比较两者的异同点有一定意义。鉴定于目前国际上对贲门癌的定义尚无统一的定论,胃食管交界处肿瘤的分类方法较多,根据Siewert的分类方法,食管腺癌和贲门癌的临床特征、淋巴结播散类型、发病机制和某些生物学标记物表达水平均有些不同,最新的检测技术如细胞角质蛋白染色法、Das-1单克隆抗体反应、硫粘蛋白克隆型表达技术等对两者的鉴别价值尚在确定中。Both of esophageal adenocarcinoma and cardia adenocarcinoma are clinically common upper gastrointestinal malignant tumours. Their definitions are different, but there are some overlaps, especially between the adenoearcinoma of distal esophagus and the cardia adenocarcinoma. We have to discriminate them clinically to guide clinical therapy and judge prognosis. But there is no intermational consensus conclusion of cardia adenoearcinoma at present. According to Siewert＇s classification there are some differences between esophageal adenocarcinoma and cardia adenocarcinoma in clinical features, scattering type of lymph glands, pathogenesis and some biological markers＇expressing level. Whether the latest detecting techniques, such as Cytokeratin staining method, Das-1 monoclonal antibody response and Sulfamucin clonotype expressing technique could be applied to identify the two tumours yet is to be determined.

关 键 词：食管腺癌 贲门腺癌 胃食管交界处腺癌 生物学标记物 

分 类 号：R735[医药卫生—肿瘤]