酒客乐对酒精性肝损伤的疗效及其机制研究  

Efficacy and mechanisms of Jiukele on prevention and treatment of experimental alcoholic liver injury in rats

作　　者：陈宏慈[1] 甘爱萍[1] 

机构地区：[1]湖北省中医院综合科,湖北武汉430061

出　　处：《中国中西医结合消化杂志》2007年第3期159-161,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：湖北省教育委员会重点科研项目(96A029)

摘　　要：[目的]探讨酒客乐对酒精性肝损伤的防治作用及其机制。[方法]采用白酒、吡唑、橄榄油的混合液制成酒精性肝损伤大鼠模型,观察酒客乐对酒精性肝损伤大鼠肝组织匀浆超氧化物歧化酶(SOD)活性、脂质过氧化代谢终产物丙二醛(MDA)水平的影响,并观察肝组织病理学改变。[结果]酒精可使大鼠肝组织SOD活性降低,MDA水平升高,而酒客乐能明显提高SOD活性(P<0.01),降低MDA的水平(P<0.05),病理观察结果能明显减轻酒精所致的肝脏损伤。[结论]酒客乐具有防治酒精性肝损伤的作用,其作用机制可能与直接抑制脂肪肝的形成、清除自由基、抗脂质过氧化等有关。[Objective]To investigate the efficacy of Jiukele on prevention and treatment of liver injury induced by ethanol in rats and its possible mechanism.[Methods]The model of alcoholic liver injury in rats was induced by the mixture of alcohol, pyrazole. MDA. SOD activity in liver homogenate were determined. Pathology of liver was observed. [Results] Alcohol inhibited SOD activity in liver tissue of rats, raised the contents of MDA, but Jiukele could significantly improved the activity of SOD in liver homogenate（P〈0. 01） ,decreased MDA contents （P〈0. 05） ,and the pathological injury induced by ethanol was greatly improved after administration of Jiukele. [Conclusion ]Jiukele has effects in prophylaxis and the treatment of alcoholic liver diseases in rats. The mechanisms may be contributed to inhibit the formation of fatty liver , eliminate free radicals, reduce lipid peroxidation, etc.

关 键 词：酒客乐 肝炎 酒精性 大鼠 

分 类 号：R575.1[医药卫生—消化系统]