中药提取物甘舒胶囊对小鼠急性酒精中毒的作用及其机制  

Effects of Ganshu capsule on acute alcohol toxication and its underlying mechanisms in the mice

作　　者：曾颖 赵春梅[2] 严群超[3] 职君利[4] 郭瑞鲜[2] 冯鉴强[2] 陈培熹 

机构地区：[1]番禺中医院,广州番禺510000 [2]中山大学中山医学院生理学教研室,广东广州510080 [3]暨南大学医学院,广东广州510000 [4]广东药学院,广东广州510000

出　　处：《解剖学研究》2007年第3期181-182,185,共3页Anatomy Research

基　　金：广州市番禺区卫生局2005年科研基金

摘　　要：目的探讨中药提取物甘舒胶囊的解酒功能及有关机制。方法应用二锅头白酒(56°),在雄性昆明种小鼠建立急性酒精中毒动物模型,分别观察甘舒胶囊对小鼠的醉酒时间、醒酒时间。肝组织中的丙二醛(MDA)及还原型谷胱甘肽(GSH)含量的影响。结果甘舒胶囊可显著地延长小鼠的醉酒时间,缩短醒酒时间,并能明显抑制乙醇引起的小鼠肝组织中的MDA含量的增多及对抗乙醇对GSH的抑制作用。结论甘舒胶囊具有显著的解酒作用,此作用可能与其抑制肝组织中的MDA含量及提高GSH水平等的抗氧化作用有关。Objective To investigate the effects of Ganshu capsule on anti-temulence and the related underlying mechanisms. Methods The male Kunming mice （SPF） were used to establish the animal model of acute alcohol toxication. The effects of Ganshu capsule on the levels of malondialdrhyde （MDA） and reduced glutathione （GSH） in hepatic tissue was observed on drunkenness time and awakening time from drunkenness. Results Ganshu capsule obviously prolonged the drunkenness time and shortened the awakening time. In addition, Ganshu capsule considerably reduced an increase in MDA induced by 56% alcohol in hepatic tissue and blocked the inhibition of alcohol on GSH level. Conclusion Ganshu capsule has effect of anti-temulence, which is associated with its roles in the inhibition on MDA production and enhancement of GSH level.

关 键 词：甘舒胶囊 急性酒精中毒 解酒作用 丙二醛 还原型谷胱甘肽 

分 类 号：R285.5[医药卫生—中药学]