The significance of proto-oncogene HGF/SF receptor c-Met mRNA expression in nasopharyngeal carcinoma  

作　　者：Chongmei Liu Zhiming Liu Minzheng Ying Minghui Lin Jie Wang Ming Mao 

机构地区：[1]Department of Pathology, Yueyang Second People＇s Hospital, Yueyang Cancer Hospital of Hunan Province, Yueyang414000, China [2]Department of Otolaryngology, Yueyang Second People＇s Hospital, Yueyang Cancer Hospital of Hunan Province, Yueyang 414000, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2007年第3期278-281,共4页中德临床肿瘤学杂志（英文版）

摘　　要：Objective: To explore the expression of c-Met mRNA in nasopharyngeal carcinomas (NPC) and its relation with clinical biological behavior. Methods: In situ hybridisation was used to detect mRNA expression of c-Met in 15 cases of non-tumor nasopharyngeal (NP), 55 cases of NPC. Results: The positive rates of c-Met mRNA in NP and NPC cells were 13.3% (2/15) and 61.8% (34/55) respectively. The expression of c-Met mRNA was significantly correlated with lymph node metastasis, local invasion (skull base erosion), and clinical stage. In cases with cervical lymph node metastasis, local invasion, and clinical stage III and IV (UICC), the positive rates of expression of c-Met mRNA were significantly higher than that in those without the conditions mentioned above (P < 0.05 or P < 0.01). But it was not significantly correlated with age, gender, histo- logic grade, and cranial nerve palsy (P > 0.05). Conclusion: The abnormal expression of c-Met gene was well correlated with the biological behavior of metastasis and invasion. To detection the expression of c-Met mRNA could serve as an important index to estimate the prognosis of NPC. C-Met may be a new diagnostic/therapeutic target of NPC.

关 键 词：hepatocyte growth factor （HGF） oncogene c-Met nasopharyngeal carcinoma invasion metastasis 

分 类 号：R739.6[医药卫生—肿瘤]