癌性胸液中4种标志物水平的检测及临床意义  

Detection of four kinds of markers in carcinous hydrothorax and its clinical significance

作　　者：朱张国[1] 阎红娥[1] 鲍文华[1] 

机构地区：[1]佳木斯大学附属第一医院呼吸内科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2007年第3期18-19,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的：探讨癌胚抗原（CEA）、腺苷酸脱氨酶（ADA）、肿瘤坏死因子-α（TNF-α）、糖链抗原50（CA50）对癌性胸液的鉴别诊断价值。方法：收集我院2005—09-2006—07呼吸科住院的胸腔积液患者胸液共73份,分别测定4种标志物的含量。结果：各标志物在癌性胸液的阳性率由高到低依次为ADA（96.8%）〉TNF-α（87.1%）〉CEA（74.2%）〉CA50（67.7%）,特异性依次为CA50（95.8%）〉CEA（95.5%）〉ADA（86.4%）〉TNF-α（62.2%）。CA50和CEA对癌性胸液诊断的特异性均较高,但阳性率不如ADA和TNF-α高。结论：联合检测CA50和CEA对癌性胸液具有较高的特异性诊断价值,而ADA的检测对良恶性胸液的鉴别诊断具有较高的阳性率。Abstract.Objective.To evaluate CEA,ADA,TNF-α and CA 50 in differential diagnosis of carcinous hydrothorax. Methods.We collected 73 portions of the pleural effusion from patients treated in Respiratory Department of our hospital during Sep. 2005 to Jul. 2006. The levels of 4 kinds of markers in pleural effusion were measured by using different methods respectively. Results：The sensitivity of all markers in carcinous hydrothorax was ADA （96. 8%）〉TNF-α（87. 1%）〉CEA（74. 2%）〉CA50（67. 7%）, respectively. And their specificity was CAS0 （95. 8%） 〉 CEA （95. 5%） 〉 ADA （86. 4%） 〉 TNF-α （62.2%）, respectively. The specificity of CA50 and CEA was higher than the others in the diagnosis of carcinous hydrothorax, while their sensitivity was lower. Conclusion. The specificity of combination of CA50 and CEA in the pleural effusion is higher than that of one marker in the diagnosis of carcinous hydrothorax. But the sensitivity of ADA detection is the highest in all markers to diagnose the quality of pleural effusion.

关 键 词：标志物 胸腔积液 诊断 

分 类 号：R730.43[医药卫生—肿瘤]