糖尿病视网膜病变患者血清中C反应蛋白的测定  

Determination and significance of serum levels of C - reactive protein in patients with diabetic retinopathy

作　　者：韦斌[1] 付玲玲[1] 具尔提[2] 王星瑾[1] 

机构地区：[1]新疆维吾尔自治区克拉玛依市中心医院眼科,克拉玛依834000 [2]新疆医科大学第一附属医院

出　　处：《中原医刊》2007年第12期5-6,共2页Central Plains Medical Journal

摘　　要：目的分析糖尿病视网膜病变（DR）患者血清中C反应蛋白（CRP）与对照组含量上有无差异,从而对DR发病机制进行探讨。方法DR患者216例,根据眼底荧光血管造影（FFA）及眼底检查结果分成背景性DR（BDR）组104例与增生性DR（PDR）组112例。正常对照（NC）组100例。三组年龄、性别差异无统计学意义。CRP采用免疫透射比浊法检测。结果BDR组、PDR组和NC组血清中CRP含量分别为（3.8±1.0）mg/L、（4.1±1.2）mg/L和（1.3±1.2）mg/L。BDR组、PDR组血清中CRP含量与NC组比较,差异均有统计学意义（P〈0.01）。但BDR组与PDR组进行血清中CRP含量比较,差异无统计学意义（P〉0.05）。结论DR患者血清中CRP含量明显高于对照组。提示炎症反应可能在DR发病机制中起着重要的作用。Objective To assess the role of the inflammatory reaction in pathogenesis of diabetic retinopathy（DR） by analyzing the difference of C -reactive protein（CRP） level in the serum between patients With DR and control group. Methods Two hundred and sixteen DR patients were divided into 104 cases of BDR group and 112 cases of PDR group according to fundus fluorescence angiography（FFA） and fundus examination. CRP were assayed in DR patients and 100 cases of NC group by Immunonephelmyfry. Results CRP concentrations in BDR group,PDR group and NC group were （3.8 ± 1.0） mg/L, （4.1 ± 1.2） mg/L and （ 1.3 ± 1.2） mg/L respectively. The mean concentrations of CRP in BDR group and PDR group were significantly higher than that of NC group （ P 〈 0. 01 ）. There were no significant differences between BDR group and PDR group （ P 〉 0. 05）. Conclusion The levels of CRP in the serum of patients with DR were higher observably than that of control group. The alteration of CRP in patients with DR supports our hypothesis that the inflammatory reaction may play an important role in the initiation and sustainment of DR.

关 键 词：糖尿病视网膜病变 C反应蛋白 炎症反应 发病机制 

分 类 号：R77[医药卫生—眼科] R587[医药卫生—临床医学]