环氧化酶-2及表皮生长因子受体在非小细胞肺癌组织中的表达及临床意义  

Expressions of cyclooxygenase-2 and epidermal growth factor receptor in non-small cell lung cancer

作　　者：董西林[1] 张勇[2] 谢明[3] 

机构地区：[1]西安交通大学医学院第二附属医院呼吸科,陕西西安710004 [2]西安市第一医院呼吸科,陕西西安710002 [3]西安交通大学医学院免疫学与病原生物学系,陕西西安7100061

出　　处：《西安交通大学学报（医学版）》2007年第3期276-278,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技攻关资助项目(No.2002K10-G3)

摘　　要：目的探讨环氧化酶-2(COX-2)与表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)组织中的表达及与肺癌发生发展的关系。方法采用免疫组化(SP)法检测56例NSCLC和20例正常肺组织中COX-2与EGFR的表达。结果56例NSCLC组织中,COX-2与EGFR表达阳性率分别为64.2%和67.8%,显著高于正常肺组织(P<0.01),COX-2与EGFR表达与临床分期、病理分级、组织学分型和淋巴结转移密切相关(P<0.05),肿瘤分期愈晚,细胞分化越差,淋巴结转移越高,COX-2与EGFR表达阳性率越高,腺癌中COX-2表达明显高于鳞癌,鳞癌中EGFR表达高于腺癌(P<0.05)。结论COX-2与EGFR在NSCLC中异常表达说明其在肺癌发生发展中有重要作用,可作为判断NSCLC的生物学行为及估计预后的指标。Objective To study the expressions of cyclooxygenase-2 （COX-2） and epidermal growth factor receptor （EGFR） in tumor tissues and explore the effect of COX-2 and EGFR in NSCLC development. Methods The expression of COX-2 and EGFR was detected by immunohistochemical technique in 56 cases of non-small cell lung cancer （NSCLC） and in 20 cases of normal lung tissues. Results The expression of COX-2 and EGFR in NSCLC was significantly higher than that in normal lung tissues （P〈0.01）, the positive expression rate of COX-2 and EGFR being 64.2% and 67.8%, respectively. The expression of COX-2 and EGFR in NSCLC was associated with clinical stage, histologic grade, tumor pathological type and lymponode metastasis （P〈0.05）. The expression of COX-2 and EGFR in stage III and stage IV of NSCLC was significantly higher than that in stage I and stage II of NSCLC. The expression of COX-2 and EGFR in the poorly-differentiated NSCLC was significantly higher than that in the well-differentiated NSCLC, and lymponode metastasis in NSCLC was higher than non-lymponode metastasis （P〈0.05）. The expression of COX-2 in adenocarcinoma cell was obviously higher than that in squmaous cell carcinoma; the expression of EGFR in squmaous cell carcinoma was higher than that in adenocarcinoma cell （P〈0.05）. The positive correlation was found between COX-2 and EGFR. Gonclusion The experiment suggests that COX-2 and EGFR play roles in oncogenesis and progression of NSCLC. Therefore, the expression of COX-2 and EGFR seems to be a useful tumor marker for patients with NSCLC and can be used to evaluate the tumor biological behavior and prognosis.

关 键 词：环氧化酶 表皮生长因子受体 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]