β-分泌酶与阿尔茨海默病  

β-secretase and Alzhemier's Disease

作　　者：方欣[1] 杨吉平[1] 赖红[1] 

机构地区：[1]中国医科大学基础医学院解剖教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2007年第2期183-185,共3页Progress of Anatomical Sciences

基　　金：辽宁省自然科学基金资助项目(No20062088).

摘　　要：β-分泌酶(β-site APP cleaving enzyme,BACE)在β位点裂解β淀粉样蛋白前体蛋白(β-amyloid precursor protein,APP)并产生β淀粉样蛋白(amyloid proteinβ,Aβ),Aβ的聚集是形成阿尔茨海默病(Alzhemier’s disease,AD)患者脑中老年斑的主要原因,引起神经元损伤和认知功能减退,在AD的发病过程中起到中心和共同通道的作用。BACE的抑制剂部分抑制BACE,可使Aβ水平下降,取得明显疗效。进一步研究BACE抑制剂的作用机制,对AD治疗具有良好的前景。β -secretase initiates the cleavage of β -amyloid precursor protein（APP）leading to the production of amyloid- β （A β）, the gathering of A β is the main cause of senile plaque in the brain of AD patient, causes neuron damage and the hypofuction of cognition, works as the center and co-gallery role in the pathogenesis of AD. The sup pressant＇s partial inhibition of BACE can decrease the production of A β and get manifest therapeutic effect. Further study of the way how BACE inhibitors work has favourable perspective in the treatment of AD.

关 键 词：阿尔茨海默病 Β-分泌酶 β淀粉样蛋白前体蛋白 protein ACE抑制剂 认知功能减退 BACE 神经元损伤 

分 类 号：R749.16[医药卫生—神经病学与精神病学]