The comparison of hippocampal pathology between patients with intractable epileptic temporal lobe epilepsy and epileptiform rats  

作　　者：陈功 

机构地区：[1]Dept Neurosurg,Affil Huashan Fudan Univ,Shanghai 200040

出　　处：《China Medical Abstracts》2007年第2期125-126,共2页中国医学文摘（外科学分册英文版）

摘　　要：Objective To study degeneration,apoptosis and loss of hippocampal neurons from patients with intractable temporal lobe epilepsy （TLE）, and compare with those from epileptiform rats. Methods After established an animal epilepsy model induced by anti-brain antibody （Munc18） with chronic kinding way in rats,and rats with both epileptiform electroencephalogram and epileptiform activity （at least four weeks） were selected and executed. There were 14 samples of hippocampus and temporal lobe from patients with intractable TLE. Sections from brain samples were investigated for degeneration, apoptosis and loss of neurons by Nissle staining and TUNEL.

关 键 词：海马趾 病理学 癫痫患者 症状 

分 类 号：R74[医药卫生—神经病学与精神病学]