术前动脉化疗对膀胱移行细胞癌ras-p21表达及预后的影响  

Effect of preoperative arterial chemotherapy on the expression of ras-p21 in the bladder transitional cell carcinoma and its prognostic value

作　　者：李长福[1] 孔祥波[2] 李彦生[1] 

机构地区：[1]哈尔滨医科大学第三临床医学院泌尿外科,黑龙江哈尔滨150081 [2]吉林大学中日联谊医院泌尿外科,吉林长春130031

出　　处：《哈尔滨医科大学学报》2007年第3期227-229,共3页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D-0032)

摘　　要：目的研究术前腹壁下动脉插管化疗对膀胱移行细胞癌ras-p21表达及预后的影响。方法术前动脉化疗组44例术前盆腔区域化疗1周（1疗程）,再行开放手术;单纯手术对照组68例单纯行开放手术。采集肿瘤标本,行ras-p21的免疫组织化学染色,检测癌基因蛋白的表达,同时对病人随访。结果ras-p21的表达与膀胱移行细胞癌的临床分期呈正相关（P〈0.05）;术前动脉化疗组ras-p21表达阳性率为54.5%,对照组ras-p21表达阳性率为70.6%,术前动脉化疗降低T2-T4膀胱移行细胞癌的ras-p21表达阳性率（P〈0.05）;术前动脉化疗组3年复发率18.2%,5年生存率81.1%,10年生存率54.5%,对照组3年复发率55.9%,5年生存率50.0%,10年生存率26.5%。结论术前动脉化疗降低ras-p21表达,可提高膀胱移行细胞癌患者的生存率、降低复发率。Objective To observe the influence of preoperative arterial chemotherapy on ras-p21 expression in bladder transitional cell carcinoma and its prognostic value on bladder cancer. Methods One hundred and twelve patients with bladder cancer were investigated. Forty-four surgical specimens were obtained from patients treated with preoperative arterial chemotherapy; sixty-eight specimens were obtained from patients treated with surgery only. Eight specimens of human normal bladder tissue were used as control. All specimens were examined by spimmunohistochemical method, for detection of ras-p21 expressions. Results The expression of ras was closely associated with the clinical stage（P 〈 0.05）;the ras-p21 positive rate was 54.5% in the group of preoperative arterial chemotherapy; and it was 70.6% in control group; ras-p21 expression in the normal bladder tissue could not be detectable. The three-year recurrence rate,five-year survival rate and ten-year survival rate were 18.2 %, 81.8 %, and 54.5 %, respectively in preoperative arterial chemotherapy group, while those were 55.9% ,50.0% ,and 26.5%, respectively in control group. Conclusion Preoperative arterial chemotherapy can decrease the ras-p21 expression in transitional cell carcinoma of bladder,and increase the survival rate and decrease the recurrence rate of bladder cancer patients.

关 键 词：膀胱移行细胞癌 术前动脉化疗 RAS-P21 预后 

分 类 号：R737.14[医药卫生—肿瘤]