65例乳腺癌预后指标同步分析的临床意义  

Clinical Significance of Prognostic Targets Synchronously Measured in 65 Cases of Breast Cancer

作　　者：高萍[1] 周振英[1] 张军妮[1] 朱月清[1] 吴晓柳[1] 张彤[1] 赵祥生[1] 

机构地区：[1]江苏省肿瘤防治研究所

出　　处：《河南肿瘤学杂志》1997年第2期103-105,共3页Henan Journal of Oncology

摘　　要：作者对65例乳腺癌患者癌细胞进行了DNA倍体、S期细胞比率（SPF）、雌激素受体（ER）和淋巴结转移（IN－ra）同步检测，并对患者进行了术后5年生存率随访。结果表明，乳腺癌患者中，异倍体者、SPF增高者、皿（－）者和LNM（＋）者的各项指标均显著高于相应的二倍体者、SPF不增高者、ER（＋）者和LNM（－）者（P＜0．05和P＜0．01），而且各项指标间是相互关联的。根据患者对各项指标反应的不同，把患者分为5级，并对其进行术后5年生存率的比较。结果发现，随患者分级增加，患者5年生存率逐渐降低。因此，本文认为，同步检测这些指标，对乳腺癌患者的预后预测和术后分组治疗都有一定实际意义。DAN ploid, proliferous achvity (S-phase fraction, SPF), estrogen receptor(ER) level, and lymphnode metastasis (LNM) were syncfornously meased on cancer cells of 65 Patients with bnat cancer.5- year suwival rae was observed aller operation in these Patients. The results showed that vedous aptsof peents with aneuploid, Paients with SPF incnd, PahentS with ER (- ), and PatientS with LNM(+ ) in all PatientS with breast cancer were Separately significantly higher than those of Patients withddeid, Patients with SPF not inced, potients with ER(+ ), and Paients with LNM (- ) (P < 0.05or P < 0. 0l ). Relationship was clase aInong various targets. The Patients were clissilied into 5grades onthe basis of different reactions of the mpts. When Comparde the ostoperative 5 - year surrival raee of 5eds, we foUn that the 5 - year swhval rate was ~ually decreased with the incax of ~es.Thus, synhInnous tests of these targets can Provide ceItain biological evidence for the individual treatmentand prognosis o0f Patients with breast cancer.

关 键 词：乳腺癌 流式细胞术 免疫组化 预后 DNA含量 

分 类 号：R737.9[医药卫生—肿瘤]