人涎腺腺样囊性癌嗜神经侵袭的动物实验研究  

Experimental study on neural invasion of human salivary adenoid cystic carcinoma

作　　者：谭爱兴[1] 孙沫逸[1] 董绍忠[2] 李建虎[1] 余立强[1] 吴燕 程晓兵[1] 

机构地区：[1]第四军医大学口腔医学院口腔颌面-头颈肿瘤外科,陕西西安710032 [2]第四军医大学口腔医学院病理科 [3]宝鸡市解放军第537医院五官科

出　　处：《北京口腔医学》2007年第3期126-128,149,共4页Beijing Journal of Stomatology

基　　金：国家自然科学基金(No.30271424);陕西省自然科学基金(No.2002C2-06)

摘　　要：目的探讨人涎腺腺样囊性癌对神经的侵袭情况。方法将30只裸鼠平均分为三组,采用Acc-M,Tca-8113及Eca-109三种细胞系分别接种于10只裸鼠的坐骨神经附近,28天后同时处理所有被接种的裸鼠,以对比这三种细胞系成瘤后对神经的侵袭情况。结果Acc-M组有90%发生神经侵袭,远远高于Tca-8113组15%及Eca-109组10%(P<0.001)。结论腺样囊性癌嗜神经侵袭是其特征性生物学行为。Objective To investigate the neural invasion of human salivary adenoid cystic carcinoma. Methods Thirty nude mice were divided equally into three groups. Acc-M ,Tca-8113 and Eca-109 cells were injected respectively into intramusculary tissue of nearby double lateral sciatic nerve of each group （ ten nude mice ）. All nude mice were sacrificed 28 days after inoculation. The circumstance of neural invasion of the three different inoculated carcinoma were compared. Results 90% of mice carrying tumor presented neural invasion in Acc-M group, over 15 % in Tea-8113 group and 10 % in Eca-109 group（ P 〈 0. 001 ）. Conclusion Neural invasion is specific biological behaviour of adonoid cystic carcinoma.

关 键 词：腺样囊性癌 坐骨神经 神经侵袭 裸鼠 

分 类 号：R739.8[医药卫生—肿瘤]