Effects of different nerve autografts on greater auricular nerve deficit in rabbits  

作　　者：Shaozong Chen 

机构地区：[1]Department of Plastic Surgery and Bums, Tangdu Hospital, Fourth Military Medical University of Chinese PLA, Xi＇an 710038, Shaanxi Province, China

出　　处：《Neural Regeneration Research》2007年第5期286-290,共5页中国神经再生研究（英文版）

摘　　要：BACKGROUND： Autograft is commonly used to repair nerve deficit. Usually, the choice of donor nerves is based on their similarities in form and structures to the injured nerves. For the reason, the cutaneous antebrachii lateralis nerve is currently considered the most suited for digital nerve repair. OBJECTIVE： To compare early nerve regeneration after transplantation of three different autografts： the greater auricular nerve （GAN）, the saphenous nerve （SN） and the lateral femoral cutaneous nerve （LFCN）. DESIGN： Observational contrast study. SETTING： Department of Plastic Surgery and Burns, Tangdu Hospital, Fourth Military Medical University of Chinese PLA. MATERIALS： A total of 42 New Zealand rabbits, of both genders, 12-14 months old and weighing 2.0- 2.5 kg, were used in this study. In addition, Moller-spetra 900 operating microscope （Germany）, Olympus BX 51 microscope, DP 70 image collecting System （Japan）, BL-420E＋ Biologic function testing System （China）, JEM-100 electron microscope （Japan）, Reichet-JunG820 Cryostat （Swiss）, and Libror-AEG-120 precision analytical Balance （Japan） were also used in this study. METHODS： The experiment was carried out in the Department of Plastic Surgery and Burns, Tangdu Hospital, Fourth Military Medical University of Chinese PLA from April to November 2005. After anaesthesia, the GAN were dissected bilaterally and a 1.2 cm deficit was made in each nerve. The animals were randomly divided into three groups, including GAN group, SN group and LFCN group with 14 in each group. ① Nerve pinch test： At 1, 2, and 4 weeks after operation, three animals in each group were tested. The nerve grafts, along with the proximal and distal GAN segments were exposed and pinched with microsurgical forceps in distal-proximal orientations. The distance between the proximal anastomosis site and the most distal point, where the pinch evoked an ear contraction response, was measured as distance of nerve regeneration. ② Computer image analysis�BACKGROUND： Autograft is commonly used to repair nerve deficit. Usually, the choice of donor nerves is based on their similarities in form and structures to the injured nerves. For the reason, the cutaneous antebrachii lateralis nerve is currently considered the most suited for digital nerve repair. OBJECTIVE： To compare early nerve regeneration after transplantation of three different autografts： the greater auricular nerve （GAN）, the saphenous nerve （SN） and the lateral femoral cutaneous nerve （LFCN）. DESIGN： Observational contrast study. SETTING： Department of Plastic Surgery and Burns, Tangdu Hospital, Fourth Military Medical University of Chinese PLA. MATERIALS： A total of 42 New Zealand rabbits, of both genders, 12-14 months old and weighing 2.0- 2.5 kg, were used in this study. In addition, Moller-spetra 900 operating microscope （Germany）, Olympus BX 51 microscope, DP 70 image collecting System （Japan）, BL-420E＋ Biologic function testing System （China）, JEM-100 electron microscope （Japan）, Reichet-JunG820 Cryostat （Swiss）, and Libror-AEG-120 precision analytical Balance （Japan） were also used in this study. METHODS： The experiment was carried out in the Department of Plastic Surgery and Burns, Tangdu Hospital, Fourth Military Medical University of Chinese PLA from April to November 2005. After anaesthesia, the GAN were dissected bilaterally and a 1.2 cm deficit was made in each nerve. The animals were randomly divided into three groups, including GAN group, SN group and LFCN group with 14 in each group. ① Nerve pinch test： At 1, 2, and 4 weeks after operation, three animals in each group were tested. The nerve grafts, along with the proximal and distal GAN segments were exposed and pinched with microsurgical forceps in distal-proximal orientations. The distance between the proximal anastomosis site and the most distal point, where the pinch evoked an ear contraction response, was measured as distance of nerve regeneration. ② Computer image analysis�

关 键 词：nerve deficit AUTOGRAFT option bridge nerve regeneration 

分 类 号：R-332[医药卫生]