生姜醇提取物对亚急性衰老小鼠抗脂质过氧化作用的研究  

STUDY ON ANTI-LIPID PEROXIDE EFFECT OF ZINGIBER EXTRACT WITH ALCOHOL IN THE SUBACUTE AGING MICE

作　　者：曹亚军[1] 马建慧[1] 陈虹[1] 李丽燕[1] 

机构地区：[1]省部共建新疆特种植物药资源重点实验室,石河子大学药学院,新疆石河子832002

出　　处：《现代预防医学》2007年第12期2253-2254,2257,共3页Modern Preventive Medicine

摘　　要：[目的]研究生姜醇提取物对实验性衰老小鼠的抗脂质过氧化作用。[方法]用D-半乳糖复制亚急性衰老小鼠模型,同时给予两种不同剂量的生姜提取物,实验6周后处死动物,测定血清、肝匀浆和脑匀浆中丙二醛(MDA)的含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性。[结果]生姜提取物能显著提高衰老小鼠血清、肝脏和脑组织中的SOD、GSH-Px的活性,降低衰老小鼠血清、肝脏和脑组织中的MDA含量。[结论]生姜提取物有抗衰老作用,可能与其提高抗氧化酶活性、清除自由基、减少过氧化脂质生成有关。[Objective] To investigate anti-lipid peroxidation of Zingiber extract with alcohol in the subacote aging mice induced by D-galactose. [ Methods] The aging mice were induced by D-galactose. Meanwhile, they were treated with two doses of Zingiber extract. The contents of MDA and the activity of SOD and GSH-Px in serum, liver and brain were determined when the mice were killed after 6 weeks. [ Results] Zingiber extract could significantly improve the activity of SOD and GSH-Px, and decrease the contents of MDA in serum, liver and brain. [Conclusions] Zingiber extract has good anti-aging effects on the aging mice, which is probably due to its effects of improving antioxidation, eliminating free radicals and prohibiting lipid pcroxidation.

关 键 词：生姜提取物 衰老 脂质过氧化 

分 类 号：R282.710.5[医药卫生—中药学]