超声弹性成像诊断大鼠部分淤胆型肝纤维化的初步研究  

Primary study on the diagnostic value of elastic imaging on partial cholestatic hepatic fibrosis in rats

作　　者：袁鹰[1] 龚渭冰[1] 张守华[1] 孙郁[1] 王倩[1] 

机构地区：[1]南方医科大学南方医院超声科,广州市510515

出　　处：《临床超声医学杂志》2007年第6期326-328,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨超声弹性成像对大鼠早期肝纤维化的诊断价值。方法30只Wistar大鼠,结扎右侧胆管(包括中叶、右叶、尾状叶),人为造成部分胆汁淤积型肝纤维化,将其分成A、B、C三组。A、C两组同批手术,A组结扎大鼠右侧胆管,C组为对照组,即假手术组,仅开腹然后关腹。B组于A、C两组术后1周行手术,部位、步骤、方法同A组。于A、C两组术后2周即B组术后1周,三组同期用超声弹性成像进行观察,并予以评分。结果A组与B、C两组间比较差异有统计学意义,P<0.001;B、C两组间比较差异无统计学意义。结论超声实时弹性成像对于早期诊断大鼠肝纤维化有意义,在胆管结扎1周时的胆汁淤积、肝细胞点状坏死没有诊断价值。Objective To evaluate the diagnostic value of elastic imaging on early cholestatic hepatic fibrosis in rats. Method Thirty Wistar rats had been ligated on the right hepatic ducts to cause partial cholestatic hepatic fibrosis factitiously and were divided into A, B and C groups. Both group A and B had been ligated on the right hepatic ducts on the first and second week respectively. Group C was a control group with only a fake operation （laparotomy） at the same time with group A. On the third week, all 3 groups were assessed by elastic imaging. Results Statistic analysis indicated that there were significant differences between group A and Bor C group（P〈0.001） and there was no significant difference between group B and group C. Conclusion Elastic imaging can be applied to diagnose early hepatic fibrosis in rats. However, it has no diagnostic value on the spotty necrosis of liver cell due to cholestasis.

关 键 词：超声检查 弹性成像 肝纤维化 淤胆型 

分 类 号：R-332[医药卫生]